Second Supervisor. Dr Helen O'Hare, Department of Respiratory Sciences, University of Leicester. Bacteria colonize virtually all habitats on our planet, including soil, water, plants, animals and humans. Read more
Remote control of cellular responses based on mechanotransduction is a research field rapidly expanding both in basic research and clinical applications. Read more
Why are some individuals prone to obesity and yet others stay lean in an obesogenic environment? Obesity is highly heritable as are related metabolic traits. Read more
Bones are tightly regulated structures that remodel their structure to adapt to changes in their mechanical environment. With ageing, this mechanical response is often dampened, leading to bone loss and weakness. Read more
We are investigating the complex interplay between cell-cell signalling (quorum sensing), microbial lifestyle (i.e., free-living planktonic cultures vs sessile biofilm communities), growth phase and virulence in gram-negative bacteria. Read more
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. It is highly conserved from yeast to humans, highlighting its fundamental biological roles. Read more
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
Application deadline - midday (GMT) Friday 10 January 2025. Cells can be characterised on the genomic, transcriptomic or proteomic levels, however, there is a 4th, currently hidden level – how molecules are arranged within the cells. Read more
The PhD in Biological Sciences gives suitably qualified graduates the chance to address important biological questions. Xi'an Jiaotong-Liverpool University offers students state-of-the-art facilities and the supervision of academic staff who have trained in internationally renowned laboratories. Read more
The immune system is responsible to maintain safe environment for normal cell function. It achieves this by taking defence actions against harmful invaders but tolerance to beneficial substances. Read more
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more
Understanding how increased temperature through climate change will impact organismal development depends on identifying compensation mechanisms that ensure robustness to changing environmental inputs. Read more
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