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We have 98 cell therapy PhD Projects, Programmes & Scholarships

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cell therapy PhD Projects, Programmes & Scholarships

We have 98 cell therapy PhD Projects, Programmes & Scholarships

Advancing translational cell therapy for Hirschsprung disease

Clinical disorders characterised by neuronal loss or dysfunction in the gastrointestinal tract remain some of the most challenging to manage, with considerable morbidity and mortality and very limited treatments. Read more

Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Stochastic modelling and inference for live-cell gene expression time-series data to unravel the mechanisms of stem cell differentiation

  Research Group: Division of Statistics
This project will develop statistical methodology for noisy time-series data and stochastic computational models to analyse live-cell imaging data provided by the lab of our collaborator Dr Cerys Manning at the University of Manchester. Read more

Investigating a transplantable biomaterial for retinal cell regeneration: a promising treatment for degenerative retinal eye diseases

Replacing degenerate retinal cells with new ones using conventional biomaterials has thus far yielded limited success against degenerative retinal diseases, dry age-related macular degeneration (AMD) and subsequent geographic atrophy of the macula. Read more

ROLE OF FOXO1 TRANSCRIPTION FACTOR IN B-CELL MALIGNANCIES

The project is focused on FoxO1 transcription factor and its role in the pathophysiology of chronic lymphocytic leukemia (CLL). Although the therapy of CLL has made several remarkable improvements, the disease still remains incurable. Read more

Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

  Research Group: Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more

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