Imperial College London Featured PhD Programmes
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cell therapy PhD Projects, Programs & Scholarships

We have 136 cell therapy PhD Projects, Programs & Scholarships

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We have 136 cell therapy PhD Projects, Programs & Scholarships

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Cancer: Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC). Read more

Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more

Characterisation of DNA-protein crosslink proteolysis repair in cancer therapy with the focus on trapped-PARP1 toxicity

DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA. DPCs are induced by endogenous aldehydes, chemotherapeutic drugs (such as PARP1 inhibitors) and ionising radiation in hypoxic cells. Read more

Cancer: Repurposing drugs as new treatments for breast cancer

Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more

From basic biology to novel translational applications of haematopoietic stem cells

The Wilkinson group focuses on the biology and translational applications of blood-forming haematopoietic stem cells (HSCs). In cancer evolution and its therapy, HSCs may play the part of the villain or the hero. Read more

EASTBIO: Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signaling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

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