TO APPLY CLICK 'INSTITUTION WEBSITE' . γδ T cells are a rare population of T cell receptor-expressing cells that function like innate immune cells.γδ T cells consist of several different subtypes that can promote or prevent cancer progression, depending on the cytokines and cytotoxic molecules they express. Read more
The advance of chimeric antigen receptor (CAR) technology has been a breakthrough in cancer immunotherapy. However, it is not clear in which subpopulation of immune cells the endowment of CAR will be most effective in treating cancer. Read more
Cancer stem cells are a small population of cells in tumours maintaining the tumorigenic capacity (1). They are featured as quiescent (i.e., dormant), in contrast to the majority of cancer cells that actively proliferate under the aberrant regulation. Read more
Blood cell differentiation is one of the best characterised models to study how normal tissue-specific stem cells give rise to diverse cell types. Read more
Blood cell differentiation is one of the best characterised models to study how normal tissue-specific stem cells give rise to diverse cell types. Read more
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
The progression of type 2 diabetes (T2D) involves development of insulin resistance that is frequently associated with obesity and that is initially compensated by increased insulin secretion from pancreatic β-cells. Read more
There are two parallel studentships on offer. One (this project) is a wet lab project and the other is a bioinformatics project. Both are addressing the fact that multiple myeloma (MM) (a blood cancer of antibody producing cells) is nearly always diagnosed late. Read more
Cellular senescence is a mechanism that is activated in stressed cells to prevent the replication of damaged DNA. Senescent cells are found in vessel walls as well as in other tissues and have been shown to play a role in ageing and age-related diseases such as cardiovascular disease. Read more
Pannexins are a family of proteins that are evolutionary related to the gap-junction forming proteins, innexins (1). Three members have been identified, Panx1, Panx2 and Panx3, and they show distinct tissue distribution. Read more
The Leishmaniases are a group of neglected tropical diseases caused by >20 species of Leishmania parasites that are spread by >90 species of phlebotomine sand flies. 1 billion people in Africa, Asia, the Americas and the Mediterranean are at risk, with the poor and malnourished being disproportionately affected. Read more
Project Overview. Heart failure is a leading cause of morbidity and mortality worldwide. In terms of volume, the normal heart is composed mostly of terminally-differentiated contractile cells (cardiomyocytes), responsible for the pump action of the heart. Read more
It has become clear in recent years that bacterial pathogens, within their mammalian hosts, can enter a quiescent state where metabolism is partially switched… Read more
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