Background. Haematopoietic stem cells (HSC) emerge from the endothelium of the embryonic dorsal aorta through the process called endothelial-to-haematopoietic transition (EHT). Read more
Image based profiling is prevalent using clinical imaging modalities such as MRI, CT and PET. Sophisticated AI techniques to aid in diagnostics have arisen owing to the rich high-dimensional data present within images that is difficult or not possible to detect with human perception. Read more
Centrioles are microtubule-based structures that form two different important cellular organelles. centrosomes and cilia. Centrosomes organise the microtubule cytoskeleton, and consequently have critical roles in cell division and cell polarity. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Project start date. October 1st 2025 [Deadline for applications. 1st August 2025]. January 1st 2026 [Deadline for applications. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Project start date. October 1st 2025 [Deadline for applications. 1st August 2025]. January 1st 2026 [Deadline for applications. Read more
Background . Platelets are small anuclear blood cells that reside within the peripheral circulation. They form the cellular foundation of the blood clotting system, so are critical for us to maintain a healthy life. Read more
Lipid nanoparticles (LNPs) are one of the most exciting medical technologies developed over the last few decades. These synthetic structures allow nucleic acids, such as oligonucleotides or mRNA, to be hidden in their core and delivered to cells within the body. Read more
Project Background. Rheumatoid arthritis (RA) patients do not die from arthritis but from complications associated with this devastating chronic disease, with cardiovascular events causing around half of all deaths in these patients [1]. Read more
Using mouse embryonic development as an experimental model, our long term interest is how epigenetic information is propagated during development and erased in the context of the germ line (zygotic and germline reprogramming). Read more
Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more
Endometrial intraepithelial neoplasia (EIN) is a precancerous condition that significantly increases the risk of developing endometrioid endometrial cancer (EEC), a global health concern as EEC is the most common gynaecologic malignancy with a rapidly rising incidence. Read more
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