Understanding the mechanism of TRPC1/4/5 channel activation by the natural product tonantzitlolone
BBSRC White Rose DTP
Dr R.S. Bon, Dr S Muench, Dr M Wright
7 January 2019
The six human TRPC proteins form tetrameric cation channels that play key roles in cellular signal transduction/integration, and their implication in human disease (including anxiety disorders, renal/breast cancer, heart failure and kidney disease) has led specific TRPC channels to emerge as potential therapeutic targets in both academia and industry.
Optimal search strategies for automated, robotic material discovery
Dr J Fearnley, Prof A Cooper
30 June 2019
This position will remain open until a suitable candidate has been found. New functional materials are central to society but they can be hard to find in the laboratory because of the astronomical search space that is defined by the available atomic and molecular building blocks.
Environmental maternal effects and intergenerational inheritance
CENTA - Central England NERC Training Alliance
Dr A Pires da Silva, Dr R Allaby
21 January 2019
Project Highlights. Mechanisms by which organisms rapidly respond to sudden environmental changes. Mother senses environmental stress signals to produce stress-resistant progeny.