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chromatin PhD Projects, Programs & Scholarships

We have 48 chromatin PhD Projects, Programs & Scholarships

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  Chromatin and maintenance of genome stability
University of Bristol School of Biochemistry
  Dr A Chambers
Applications accepted all year round
Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.
Details
Type/Funding
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
University of Oxford Radcliffe Department of Medicine
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
Details
Type/Funding
  Investigating the Drosophila DF31 protein to gain insight into the mechanisms and chromatin maintenance in animal cells
St George’s, University of London Molecular and Clinical Sciences Research Institute
  Dr S Cotterill, Dr A Nohturfft
Applications accepted all year round
The Drosophila DF31 protein is an abundant ribonucleoprotein that localises to euchromatic regions and is involved in maintaining chromosome structure.
Details
Type/Funding
  Advanced microscopy analyses of SMC complex chromatin dynamics across the genome
University of Sussex School of Life Sciences
  Dr J Baxter, Dr K Chan
Application Deadline: 15 February 2019
Background. How chromosomes are organised in cells is critical for genetic function and inheritance. In all living cells SMC complexes dynamically structure chromosomes.
Details
Type/Funding
  Profiling stem cell epigenetic transitions within the Drosophila hematopoietic stem cell niche
University of Birmingham Institute of Immunology and Immunotherapy
  Dr P Badenhorst, Prof C Bonifer
Applications accepted all year round
The self-renewal and differentiation of stem cells is controlled by signals derived from the microenvironment or “niche”. The paired hematopoietic organs of the Drosophila genetic model organism are a well-characterized system in which the regulation of stem cell behaviour within a niche can be genetically dissected.
Details
Type/Funding
  A structural basis for the cross-talk between histones and RNA Polymerase II
Masaryk University CEITEC
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 3 February 2019
Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
Details
Type/Funding
  PhD project on Epigenetic Mechanisms in Neuroscience: uncovering the role of three dimensional chromatin organization
Bar-Ilan University Faculty of Medicine
  Dr E Elliott
Applications accepted all year round
We are seeking an enthusiastic student for a novel project on the epigenetic basis of behavior. The goal of the project, under the direct supervision of Dr.
Details
Type/Funding
  Elucidating the role of chromatin and epigenetic modifiers in Acute Myeloid Leukaemia.
Queen’s University Belfast School of Medicine, Dentistry & Biomedical Sciences
  Research Group: Centre for Cancer Research and Cell Biology
  Prof K Mills, Dr AT Kruythoff-Mohd Sarip
Application Deadline: 20 January 2019
Progression and characteristics of Acute myeloid leukemia (AML) has been linked to several key pathways including inactivation of tumour suppressors and gain-of-function mutation of oncogenes.
Details
Type/Funding
  Transcriptional programming of chromatin in normal and malignant haematopoiesis
University of Birmingham Institute of Cancer and Genomic Sciences
  Prof C Bonifer
Applications accepted all year round
In our work, we address the question of how the regulators of transcription, the sequence-specific DNA binding proteins or transcription factors, interact with the chromatin template and change its structure.
Details
Type/Funding
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
University of Oxford Radcliffe Department of Medicine
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019
Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
Details
Type/Funding
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