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chromatin PhD Projects, Programmes & Scholarships

We have 34 chromatin PhD Projects, Programmes & Scholarships

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We have 34 chromatin PhD Projects, Programmes & Scholarships

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Evaluation of MCT1s role in chromatin remodelling and metabolomics changes involved in cancer progression

Monocarboxylate transporter 1 (MCT1) is a transmembrane protein involved in cell metabolism and mediates transport of monocarboxylates (such as pyruvate {a metabolic substrate} and lactate {a metabolic by product}) in and out of the cell. Read more

MSc by Research: Investigating the tumor suppressor functions of chromatin remodelling

One of the unanticipated outcomes of population based genome sequencing has been the finding that genes involved in the regulation of many genes are mutated at high frequency in tissue specific cancers. Read more

Revealing epigenetic signaling mechanisms in genome regulation and cancer.

We are looking for highly motivated PhD students to join our efforts to reveal epigenetic mechanisms that regulate the function of eukaryotic genomes in health and disease. Read more

Chromatin dynamics regulating light and temperature signalling in Arabidopsis

Outline & Aim. Environmental and endogenous stimuli shape plant development, growth and photoprotection by triggering nuclear processes that lead to major changes in gene expression. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

3D genome folding and its role in DNA-based processes

The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more

Mechanisms of gene regulation shared between human development and neurodegeneration

Applications are invited for a research studentship leading to the award of a PhD degree, under the supervision of Dr. Marco Trizzino, to investigate mechanisms of gene regulation shared between human development and neurodegeneration. Read more

Defining the Epigenome in Tendon Ageing

One hallmark of ageing is the accumulation of epigenetic alterations. There is a clear link between age and increasing incidence of tendon injury suggesting that the mechanical integrity of tendon declines with age. Read more

Discovery and mechanism evaluation of synthetic lethality in cancers of mesenchyme

In order to circumvent evolutionary selection and resistance to environmental context and anti-cancer agents, novel approaches that result in synthetic (synergistic) cell lethality (dependencies) that are specific for the cancer cell are most likely to have translational impact. Read more

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