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chromosome segregation PhD Projects, Programmes & Scholarships
We have 9 chromosome segregation PhD Projects, Programmes & Scholarships
We have 9 chromosome segregation PhD Projects, Programmes & Scholarships
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Identification and functional analysis of novel factors driving meiotic chromosome segregation in Caenorhabditis elegans
We are interested in identifying new factors involved in promoting faithful chromosome segregation during meiosis. From previous mass spectrometry-based screenings we have isolated several uncharacterized proteins that seem to hold important roles in crossover formation and DNA repair. Read more
MSc by Research: Identification of PP2A substrates during oocyte meiosis
Female meiosis is particularly error-prone, leading to chromosomally abnormal embryos that account for >10% of human pregnancies and, for women nearing menopause, the incidence may exceed 50%. Read more
Homologous recombination at human centromeres – friend or foe?
The centromere is a region of chromatin that serves as a platform for the kinetochore machinery assembly, hence is essential for accurate chromosome segregation during cell division. Read more
How does paclitaxel kill cells and why do some cells evade it?
Paclitaxel (Taxol) is a microtubule-stabilizing drug widely used for the treatment of breast, ovarian and lung cancers. For many years, it was thought to kill cancer cells by inducing mitotic arrest, thus preventing proliferation. Read more
3D genome folding and its role in DNA-based processes
The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more
Molecular mechanisms safe-guarding genome stability during mammalian cell division
Faithful cell division ensures the correct segregation of the genetic material over multiple generations. Failure of this process may result in cell death or trigger tumorigenesis. Read more
How does the TRAIP ubiquitin ligase guard the mammalian genome from damage?
The TRAIP ubiquitin ligase is a key regulator of genome integrity in mammalian cells. The importance of TRAIP is highlighted by the fact that mutation leads to a human disease syndrome, whilst over-expression of TRAIP can be associated with human cancer. Read more
Unlocking the potential of a novel microtubule growth inhibitor as a cancer therapeutic
Microtubules are a functionally versatile and critically important component of the cytoskeleton and as a result have been one of the most actively pursued therapeutic targets of the past 60 years. Read more
Understanding gene regulation by HDAC1 complexes in development and cancer
Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more
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