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cilia PhD Projects, Programs & Scholarships

We have 10 cilia PhD Projects, Programs & Scholarships

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  Structure studies of centrosomal and ciliary proteins to understand the molecular mechanisms of ciliopathies
  Research Group: School of Molecular and Cellular Biology
  Dr T Ochi
Application Deadline: 17 December 2018
The aim of this PhD project is to determine the molecular assembly mechanism of a structure of the centriole / basal body by a combined approach of structure biology (cryo-EM and X-ray crystallography) and biochemistry in order to understand underlying mechanisms that cause ciliopathies and cancer.
  Controlling the switch between centrosomes and cilia: how cells prevent ciliogenesis when it’s not required
  Dr C Wilkinson
Application Deadline: 15 January 2019
Cilia are hair-like organelles that project from the surface of many cells. They act as signalling masts, housing receptors that are essential for communication and environmental sensing.
  MRC DiMeN Doctoral Training Partnership: Ciliogenesis and skeletal muscle regeneration: molecular mechanisms of stem cell maintenance
  Dr A G Borycki, Prof C A Johnson
Application Deadline: 21 January 2019
Project. Ciliopathies are a group of inherited developmental disorders caused by mutations affecting the structure or function of motile and non-motile cilia.
  A molecular analysis of centrioles, centrosomes and cilia
  Prof J Raff
Application Deadline: 11 January 2019
Centrioles organise the assembly of two important cell organelles. centrosomes and the cilia.
  Defining the interplay between polycystin 1/2 signalling and cAMP signalling in different subcellular domains
  Prof M Zaccolo
Application Deadline: 25 January 2019
Primary cilia are ubiquitous organelles fundamental for vision, hearing, smell perception, breathing, excretion, reproduction and development and their disruption or loss leads to several diseases (ciliopathies).
  Imaging Life Beyond the Diffraction Limit of Light
  Dr J Malicki
Applications accepted all year round
Ever since its invention centuries ago, light microscopy has been hampered by the diffractive properties of light, which limit resolution to ca.
  Pre-clinical testing of new therapeutic treatments for cystic kidney disease
  Dr S Bell, Prof C A Johnson
Applications accepted all year round
The primary cilium on the ventral surface of most vertebrate cells acts as an “antennae” that receives and transduces chemo- and mechanosensory signals.
  Determination of the molecular architectures of centrosomes and basal bodies using a novel labelling method and cryo-electron tomography
  Research Group: BBSRC White Rose DTP
  Dr T Ochi, Dr J.H. Tomlinson
Application Deadline: 7 January 2019
This project is to determine exact locations of centrosomal and ciliary proteins by developing antibody-like proteins that can specifically recognise targets and by using cryo-electron microscopy.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round
Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  MRC DiMeN Doctoral Training Partnership: Role of primary cilium in morphogen signalling modulation by Transforming Growth Factor-beta (TGF-beta) and its involvement in tissue fibrosis and aberrant wound healing
  Dr F Del Galdo, Dr N.A. Riobo-Del Galdo
Application Deadline: 21 January 2019
We offer an exciting opportunity to investigate the molecular basis underlying tissue fibrosis, at the epigenetic, molecular and cellular level.
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