School of Molecular and Cellular Biology
Dr T Ochi
17 December 2018
The aim of this PhD project is to determine the molecular assembly mechanism of a structure of the centriole / basal body by a combined approach of structure biology (cryo-EM and X-ray crystallography) and biochemistry in order to understand underlying mechanisms that cause ciliopathies and cancer.
Primary cilia are ubiquitous organelles fundamental for vision, hearing, smell perception, breathing, excretion, reproduction and development and their disruption or loss leads to several diseases (ciliopathies).
Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).