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circadian PhD Projects, Programmes & Scholarships
We have 27 circadian PhD Projects, Programmes & Scholarships
(Bicentenary) Circadian Tick-Talking in the metabolic clock: The role of Dorsomedial Cholecystokinin neurons in the circadian regulation of metabolic activity
Our daily or circadian body clock is one of the most important timing systems in our brain and body, ensuring that our brain’s activity is appropriately aligned with our homeostatic, physiological, and behavioural needs across the day. Read more
(Bicentenary) Understanding the impact of postnatal light environment on circadian clock development and function in adulthood
Circadian rhythms are a fundamental feature of life. In mammals, these ~24h rhythms are endogenously generated by a brain clock within the suprachiasmatic nucleus (SCN) that critically synchronises body functions to the prevailing light-dark cycle. Read more
(Bicentenary) The impact of circadian desynchrony on cardiovascular function
Virtually all organisms on our planet use an internal biological clock to time, and thereby anticipate recurring fluctuations in the environment (light, temperature, food availability). Read more
Funded PhD SWBio DTP- CircadiAgeing: Clock excitability, circadian rhythms and healthy ageing
Project description. 24 hour/circadian rhythms are essential for all lifeforms, allowing physiology and behaviour to be optimally aligned to light/dark cycles. Read more
Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions
Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more
Circadian Rhythms and Ageing
About the Project. We are pleased to offer the opportunity for a self-funded PhD student to join our research team within the School of Pharmacy, University of Kent. Read more
Circadian Rhythms and Ageing
About the Project. We are pleased to offer the opportunity for a self-funded PhD student to join our research team within the School of Pharmacy, University of Kent. Read more
Circadian clock control of adipocyte metabolism
Obesity is a major public health issue affecting one third of UK adults, and an estimated 2.1 billion individuals worldwide. The role of circadian clock dysfunction in the development of obesity is becoming clear, with disruptive lifestyles (e.g. Read more
Role of the endosomal pathway in regulating sleep and circadian rhythms
Ageing and many neurodegenerative disorders are characterised by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more
MRC DiMeN Doctoral Training Partnership: Cardiovascular function around the clock: harnessing protective circadian mechanisms towards smarter design of novel retinoid therapies and lifestyle interventions
Heart failure (HF) is one of most significant contributors of mortality globally. Whilst some therapeutic options are available, half of the people die within 5 years of diagnosis, and those diagnosed with end-stage heart failure die within a year. Read more
Circadian rhythm effects on radiotherapy for prostate and other cancers
Research Group:
Human & Medical Genetics
Radiotherapy is used to treat more than 50% of cancer patients, but up to a quarter of patients suffer side effects that can affect their quality of life in the long-term. Read more
Light mediated CDK5 repression and its effects on the circadian clock and Alzheimer's disease
The deregulation of brain cells alters brain functions, leading to various neurological diseases, including Alzheimer's disease. This dysregulation can stem from kinases such as cyclin-dependent kinase 5 (CDK5), a serine/threonine protein kinase that governs important cellular processes. Read more
(Bicentenary) CIRCLE - Circadian Influence on the Regulation of Cardiac surgicaL outcomEs
For decades, scientists have observed that disease symptoms and recovery fluctuate according to the time of day1. This phenomenon, driven by our body’s internal timing mechanism – the body clock – influences everything from heart function to immune response2,3. Read more
Funded PhD SWBio DTP- Chrono-nutrition and Chrono-pharmacology: Investigating the Impact of Intermittent Fasting and Pharmacological Treatments on Extra-SCN Brain Oscillators for Obesity Management
Project description. Life on Earth is subordinate to periodic alterations in the environment, with most notable changes seen from day to night. Read more
Funded PhD - Chrono-Nutrition Meets Chrono-Pharmacology: Exploring Neurobiological Underpinnings of Intermittent Fasting and Pharmacological Interventions in Obesity Management
Life on Earth is subordinate to periodic alterations in the environment, with most notable changes seen from day to night. To react, anticipate, and adapt to these cyclic changes, living organisms evolved endogenous 24h timekeeping mechanisms named circadian clocks. Read more
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