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circadian clock PhD Projects, Programmes & Scholarships

We have 25 circadian clock PhD Projects, Programmes & Scholarships

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We have 25 circadian clock PhD Projects, Programmes & Scholarships

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The coupling between the circadian clock, metabolism and the environment: a systems’ approach

  Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)
Background. The circadian clock is a gene circuit that generates 24-h cycles of gene expression in many organisms in anticipation of daily cycles of sunlight and temperature. Read more

Circadian clock control of adipocyte metabolism

Obesity is a major public health issue affecting one third of UK adults, and an estimated 2.1 billion individuals worldwide. The role of circadian clock dysfunction in the development of obesity is becoming clear, with disruptive lifestyles (e.g. Read more

A mechanistic understanding of circadian clock-dependent regulation of the secretory pathway

The protein secretory pathway comprises a series of membranous compartments and transport vesicles that cells use to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix. Read more

Unravelling the interplay between circadian clock and stress response using neurogenetics

Molecular clock also interacts with a key kinase-signalling network called the integrated stress response (ISR) (1). Cellular stressors such as protein aggregates and reactive oxidative stress trigger ISR and modulate downstream gene transcription. Read more
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(BBSRC DTP) The role of GABA signalling in the electrical timekeeping of the master circadian clock to drive circadian rhythms

Our daily or circadian body clock is one of the most important timing systems in our body, ensuring that our brain activity is appropriately aligned with our homeostatic, physiological, and behavioural needs across the day. Read more
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EASTBIO: How the circadian clock controls immunity against infections

  Research Group: Centre for Inflammation Research
Circadian rhythms are thought to regulate all cells, including those making up the immune system. Circadian rhythm is exerted via clock-genes and is a likely reason for the increased risk of infections observed in jet-lagged individuals, or those doing shift work. Read more

Circadian rhythms in plant-microbe-soil interactions

  Research Group: CENTA - Central England NERC Training Alliance
Project Highlights. ·      Circadian clocks represent adaptations to the rhythmic nature of our environment because they allow organisms to adjust their physiology ahead of predictable daily changes in light and temperature conditions linked to the rotation of the earth. Read more

Do circadian rhythms in ion concentrations drive cellular metabolic rhythms?

  Research Group: Institute of Molecular Plant Sciences
In the living cell, virtually nothing stays the same over the day/night cycle. Endogenous ~24h rhythms are driven by a biological timekeeping system, the circadian clock, that dynamically regulates nearly all biological processes to match Earth's environmental cycle. Read more
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EASTBIO Do circadian rhythms in ion concentrations drive cellular metabolic rhythms?

  Research Group: Institute of Molecular Plant Sciences
In the living cell, virtually nothing stays the same over the day/night cycle. Endogenous ~24h rhythms are driven by a biological timekeeping system, the circadian clock, that dynamically regulates nearly all biological processes to match Earth's environmental cycle. Read more

The role of haem in plant signalling and regulation

The molecule, haem, is structurally similar to chlorophyll – both comprise a metal ion chelated by a tetrapyrrole ligand. A large number of proteins depend on haem, which can form additional bonds between the metal ion and the side chains of amino acids. Read more

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