Reference. SW44292. Dr Pau Creixell wishes to recruit a PhD student to work on the project entitled. Drugging kinase-driven brain cancer with multi-topic compounds. Read more
Cancer remains one of the most challenging diseases to treat, but recent advances in immuno-oncology (IO) offer new hope. IO therapies aim to use the body's own immune system to fight cancer. Read more
Background to the project. Frailty is a critical concept and a key contributor to overall global ageing and impacts a large global market with high public health significance. Read more
We are to understand how EVs induce and affect cardiovascular diseases. To this end, we investigate its changes in disease models of the cardiovascular system and in its comorbidities, e.g., metabolic diseases. Read more
Heart failure is the most common cause of mortality in diabetes patients, but current diabetes therapies have a limited impact on the incidence of heart failure in diabetic populations. Read more
Medulloblastoma is the most common malignant brain tumour in children. It occurs in the cerebellum and accounts for approximately a quarter of all childhood brain tumours. Read more
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
This project investigates the impact of natural genetic variations on a specific G protein-coupled receptor (GPCR), focusing on its structure, function, and drug interactions. Read more
This project seeks to achieve breakthroughs in how Central Nervous System diseases, where there is severe unmet medical need, may be addressed with small molecules. Read more
The main research activities of my research group concern the improvement of traditional drug formulation and development of novel drug and formulation strategies to enhance bioavailability and patient acceptability. Read more
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