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colon PhD Projects, Programs & Scholarships

We have 11 colon PhD Projects, Programs & Scholarships

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  G protein-coupled receptor (GPCR) signalling in the mouse and human gastrointestinal (GI) tract.
  Prof H Cox
Application Deadline: 11 January 2019
To establish the mechanisms of GPR35 signalling in the mouse and human GI tract. GPR35 is an orphan receptor that lacks an endogenous ligand but is highly expressed in mammalian GI tract, particularly in the colon and is implicated in the onset of inflammatory bowel disease (IBD).
  Identification of the cellular targets of the Malaysian phytochemical pentamethoxyflavone, a candidate agent for the chemoprevention of colorectal cancer
  Dr C Serpell, Prof M Garrett
Application Deadline: 20 January 2019
The incidence of colorectal cancer (CRC) has risen at an alarming rate in Malaysia, becoming the second most common cancer in males and third most common in females.
  What keeps the gut stem cell niche healthy? (SOBOLEWSKIAU19SF)
  Dr A Sobolewski
Applications accepted all year round
A normal functioning epithelium is vital for a healthy gut. The epithelium forms a protective barrier between the bacteria and food contents in the intestine and the underlying immune system, so preventing an immune response.
  Investigating nerve:immune cell cross talk during gut inflammation
  Dr J Pennock, Prof A MacDonald
Applications accepted all year round
The gut contains more nerves than any other part of the body outside the brain. These nerves contribute to pain responses and essential muscle movement, but their role during inflammation is not known.
  Developing an innovative gastrointestinal model to assess the effects of antimicrobial agents on the gut microbiota: microbiology and molecular mechanisms to ensure long term healthy outcomes for patients receiving treatment
  Dr S Fouch, Dr J Brown
Application Deadline: 17 February 2019
Applications are invited for a fully-funded three year PhD to commence in October 2019. The PhD will be based in the School of Pharmacy and Biomedical Sciences and will be supervised by Dr Sarah Fouch and Dr James Brown.
  Regulation of mTOR by pharmacological activators of transcription factor Nrf2
  Prof A Dinkova-Kostova
Applications accepted all year round
The mechanistic target of rapamycin (mTOR) is a kinase, which is the core component of two protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), and has a fundamental role in the maintenance of cellular homeostasis.
  The relationship between dietary iron and zinc, and the gut microbiota: Can dietary iron and zinc regime be exploited to improve health?
  Prof S C Andrews
Applications accepted all year round
"The gut microbiota (100 trillion cells) outnumber human cells by 10 to 1. Its composition of around 500 to 1000 species is specific for each individual and is dynamic, changing with age, health and diet.
  Investigating the role of the mechanosensor channel Piezo1 in human disease
  Dr K Erdmann
Application Deadline: 23 January 2019
Piezo proteins are ion channels that are gated by mechanical stimuli like stretch or shear stress. In mammalians there are two Piezo isoforms (Piezo1 and Piezo2) with largely different expression pattern.
  The interaction between genetics and environment in the development of rare tumours.
  Dr K Sisley
Application Deadline: 20 December 2018
We are an active research group investigating ocular tumours, and sarcomas, with an interest in Thyroid cancer. Both ocular tumours and sarcomas are rare compared to the more common cancers such as breast and colon, and represent an under researched area.
  Engineering bacterial therapeutics with enhanced metabolic properties
  Dr G H Thomas, Dr J P J Chong, Dr D Heeg
Application Deadline: 7 January 2019
Our understanding of the human gut microbiome is increasing at a rapid pace, to the point where important metabolic interplay between components of the community are now understood.
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