Piezo proteins are ion channels that are gated by mechanical stimuli like stretch or shear stress. In mammalians there are two Piezo isoforms (Piezo1 and Piezo2) with largely different expression pattern.
Our group is a world leader in targeting specific aspects of steroid metabolism to block cancer growth. Our research has been instrumental in the successful pre-clinical and clinical development of various novel anti-cancer compounds.
A normal functioning epithelium is vital for a healthy gut. The epithelium forms a protective barrier between the bacteria and food contents in the intestine and the underlying immune system, so preventing an immune response.
"The gut microbiota (100 trillion cells) outnumber human cells by 10 to 1. Its composition of around 500 to 1000 species is specific for each individual and is dynamic, changing with age, health and diet.