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colorectal cancer PhD Projects, Programmes & Scholarships

We have 21 colorectal cancer PhD Projects, Programmes & Scholarships

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We have 21 colorectal cancer PhD Projects, Programmes & Scholarships

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Biological significance, predictive value and targeting of cell surface antigens in colorectal cancer.

Despite major advances in its early detection, preventive measures and therapeutic options, colorectal cancer is the fourth most commonly diagnosed cancer and the third leading cause of cancer deaths worldwide. Read more
Last chance to apply

Preclinical investigation of novel super-selective mTOR inhibitors in colorectal cancer

The development of potent and selective small molecules that mediate dose-dependent inhibition of a protein in its natural environment is essential to elucidate the role of such nominated target in normal and pathological settings [1]. Read more

In situ analysis of the T-cell receptor repertoire in colorectal cancer

As cancer cells divide their DNA accumulates new mutations, some of which will lead to the generation of neoantigens – mutant peptides that can be recognised by immune cells as non-self. Read more

Using epigenetic modifiers in combination with 5-FU based chemotherapy to elicit tumour specific immune responses and immunogenic cell death in colorectal cancer.

HDAC inhibitors (HDACi) are an emergent class of epigenetic modifying agent (EMA), with multi-modal mechanisms-of-action in both tumour and tumour microenvironment (TME). This project aims to understand how these drugs modulate efficacy of 5-FU-based chemotherapy to counteract transcriptional plasticity and immune evasion that underpins emergence of treatment resistance. Read more
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A multimodal deep learning model to predict individual cancer patient survival probabilities

Can a deep learning framework that accommodates complex cancer ‘omics data, such as gene-expression data, with clinical phenotypic data enhance our ability to predict cancer patient survival?. Read more

Precision & Personalised Approaches for Treating Cancer

  Research Group: School of Physics and Astronomy
Over 10 million surgical operations are performed each year in the NHS, with patients increasingly benefiting from minimally invasive approaches with reduced morbidity, quicker return to normal function, and cost savings for the NHS. Read more
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Understanding the pro- and anti-tumour functions of IFNγ-producing γδ T cells

TO APPLY CLICK 'INSTITUTION WEBSITE' . γδ T cells are a rare population of T cell receptor-expressing cells that function like innate immune cells.γδ T cells consist of several different subtypes that can promote or prevent cancer progression, depending on the cytokines and cytotoxic molecules they express. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

How the interactome defines the biological activity of members of the KDM4A subfamily of histone demethylases.

The expression of members of the KDM4A-subfamily of histone demethylases is impaired in various cancers. Different signalling pathways regulate the KDM4A-subfamily interactome, thereby affecting the biological activity of these enzymes. Read more

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