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We have 13 cystic fibrosis PhD Projects, Programmes & Scholarships
cystic fibrosis PhD Projects, Programmes & Scholarships
We have 13 cystic fibrosis PhD Projects, Programmes & Scholarships
Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.
Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more
MScR: Cystic fibrosis: restoring ion transport with small molecules
Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a unique ATP-binding cassette transporter that functions as an ATP-gated anion channel, playing a pivotal role in salt and water movement across epithelial tissues (1). Read more
Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.
Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more
Development of Nanomaterials for Targeting the Bacteria–Host Interface in Cystic Fibrosis Airways
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more
Selective targeting of furin for the treatment of fibrotic lung disease.
Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more
FIND-BACT Study: Finding INnovative Diagnostics for BACTerial infections in children
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Detecting bacterial infection in children is very challenging, particularly in previously well children presenting to the Emergency department (ED) with fever as well as in children with chronic illnesses, such as those with cystic fibrosis (CF). Read more
Clinical: Gastroesophageal reflux in respiratory disease: pathogenic role and improved management
Gastroesophageal reflux disease (GERD) is a condition in which stomach contents, such as food and acid pass into the gullet/oesophagus causing heartburn. GERD is very common in patients with lung disease, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Read more
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Microorganisms grow as biofilms on surfaces, from teeth to surgical implants or even the lining of the lungs. Biofilms are dense cell aggregates embedded in a complex matrix of molecules that surrounds and protect the cells. Read more
RECRUITING NOW: Funded PhD Studentships at the EPSRC and MOD Centre for Doctoral Training in Complex Integrated Systems for Defence and Security (CISDnS) at the University of Southampton.
Looking to purse a PhD either full time or part time in maritime, aeronautical, aerospace, medical and electronic systems following digital, physical, biological themes then we have opportunities for you. Read more
Development of a personalized therapy for pulmonary arterial hypertension (PAH)
Research Group:
Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more
Nanoparticle delivery of antibiotics for treatment of pulmonary infection
Antimicrobial resistance (AMR) poses a major global risk to human health by causing death, disability, longer hospitalisations, and increased healthcare costs. Read more
Regulation of virulence and biofilm formation by quorum sensing and the "stress alarmone" ppGpp in gram-negative pathogenic bacteria.
We are investigating the complex interplay between cell-cell signalling (quorum sensing), microbial lifestyle (i.e., free-living planktonic cultures vs sessile biofilm communities), growth phase and virulence in gram-negative bacteria. Read more
Novel investigation of innate airways defence in Severe Asthma and elucidation of potential therapeutic targets
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Join a distinguished translational experimental group that spans from lab work to delivery of specialist asthma clinical care, seeking to understand variation in airways immunity and how this results in varied responses to current asthma therapies. Read more
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