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cystic fibrosis PhD Projects, Programs & Scholarships

We have 10 cystic fibrosis PhD Projects, Programs & Scholarships

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  Expression and purification of the cystic fibrosis transmembrane conductance regulator and development of a high throughput screen for drug discovery
  Prof R Ford
Applications accepted all year round
The cystic fibrosis transmembrane conductance regulator protein (CFTR) is a chloride channel than plays an important role in epithelial cells.
  Deciphering Aspergillus fumigatus - Pseudomonas aeruginosa synergistic interactions in coinfection
  Dr J Amich, Prof E Bignell, Dr S Fowler
Applications accepted all year round
Pathogen-pathogen interactions in polymicrobial infections are known to directly impact, often to worsen, disease outcomes. Aspergillus fumigatus is the most common fungal pathogen and Pseudomonas aeruginosa one of the most prevalent bacterial pathogens of the human lung.
  Characterising temperate bacteriophages in complex microbial communities and their role in antimicrobial resistance (Ref:SF18/APP/Smith)
  Dr D Smith
Applications accepted all year round
Temperate bacteriophages have the ability to integrate into the chromosome of their target bacterium that leads to a change in the physiology of their bacterial host.
  New antimicrobial agents for biofilm-related infections
  Dr K Fairfull-Smith
Applications accepted all year round
The adhesion of bacteria to surfaces and their subsequent ability to aggregate into colonies called biofilms is a significant problem in healthcare systems around the world.
  Pyocins as alternatives to antibiotics against Pseudomonas aeruginosa infections
  Dr C Penfold
Applications accepted all year round
Pyocins are bacteriocins produced by Pseudomonas aeruginosa to kill closely related strains of the same species during times of environmental stress.
  The interaction of bacterial biofilms with immune cells.
  Dr L Martinez-Pomares
Applications accepted all year round
Second Supervisor. Miguel Camara/Paul Williams. Project Overview. P. aeruginosa (PA) is emerging as major opportunistic pathogen of clinical relevance.
  To experimentally determine the environmental influences acting on P. aeruginosa virulence factor expression in biofilms and understand the catalytic mechanism of one of them (the surface tethered aminopeptidase AaaA)
  Dr K Hardie
Applications accepted all year round
Pseudomonas aeruginosa is an important opportunistic pathogen. It is a problem for the immunocompromised and has attained superbug notoriety since it is evident in hospitals and has inherent resistance to antibiotics.
  Structure and function of key ABC Transporters in health and disease
  Prof L Carpenter, Dr H de Wet
Application Deadline: 30 April 2019
Human ABC transporters are a family 52 integral membrane proteins that transport diverse molecules across cell membranes. Mutations in ABC transporters causes a range of diseases, including diabetes (ABCC8 and ABCC9), cystic fibrosis (ABCC7, CFTR) and blindness (ABCA4).
  Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteins
  Dr S Hyde, Dr D Gill
Application Deadline: 26 July 2019
We are focusing on strategies to deliver therapeutics via in vivo delivery of gene transfer vectors to generate ectopic “protein factories” capable of secreting therapeutic proteins into both the lung lumen and the systemic circulation.
  Development of Gene Therapy and Gene Editing for Lung Disorders: the translation of new gene therapies to the clinic, including the development of new vectors, and evaluation in animal models of disease.
  Dr D Gill, Dr S Hyde
Application Deadline: 26 July 2019
The Gene Medicine Research Group is based in the John Radcliffe Hospital and is focused on the development of new gene therapeutics for lung diesases.
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