Airway mucus plugs cause airway obstruction in patients with airways disease, such as cystic fibrosis and bronchiectasis. Little is known about the effects of therapy on plug composition, airway ventilation or clinical outcome.
Background. This interdisciplinary project bridges world-leading labs with expertise in bacterial cell biology and infection. Novel therapies are needed to overcome increasing antibacterial resistance.
Pseudomonas aeruginosa (Pa) is an important bacterial pathogen in people with cystic fibrosis and other chronic lung conditions. During early infection, Pa adapts to the environment of the respiratory tract, leading to long-lasting, difficult to treat infections.