Investigating inflammasome regulation in human myeloid cells
Centre for Experimental Medicine
Dr R Coll, Prof P Moynagh
20 January 2019
Inflammasomes are protein complexes that control inflammation in both infection and sterile injury. Aberrant inflammasome activation is a driver of many diseases including.
To determine the role of PGD2/CRTh2 axis on non-classical monocytes in asthma
Prof C Brightling, Dr A Wright
Applications accepted all year round
PGD2 stimulation of non-classical monocytes is active in asthma and promotes T2-dependent memory/effector T cell responses. The Prostaglandin D2 / prostaglandin D2 receptor (also known as CRTh2) axis plays an important role in allergic and Type 2 (T2)-mediated moderate to severe asthma [1-3].