In cardiac ventricular myocytes, transverse tubules (TT) are critical to efficient excitation-contraction coupling (ECC). During ECC, TTs allow rapid propagation of electrical excitation and voltage-gated Ltype Ca2+ current (ICa) into the cell centre. Read more
The brain is a complex network of billions of neurons structured through highly specialized compartments. dendrites that receive signals, and axons that transmit them. Read more
Question. Tyrosine phosphorylation of signalling proteins at the plasma membrane controls essential actin-dependent processes in eukaryotes, including migration, adhesion, and communication. Read more
Smooth muscle is critically important in a range of functions, from maintaining blood pressure, to squeezing food through the gut and many more. Read more
Living cells maintain and change their shape, adhere to surfaces, spread and divide by harnessing a dynamic filamentous structure termed the cytoskeleton. Read more
Autism spectrum disorders (ASDs) are increasingly common developmental disabilities, but they are not well understood. We therefore study the most common monogenetic disorder Neurofibromatosis type 1 (NF1) which affects 1/2600. Read more
This project is one of a number that are in competition for funding from the University of Bath URSA competition, for entry in September 2025. Read more
Cell migration is fundamental for the existence of multicellular animals, including humans, as certain cells migrate throughout the embryo to form specific tissues. Read more
Motor Neurone Disease (MND) is a catastrophic disease with a 100% fatality rate but is mechanistically poorly understood. Recently, αβ-integrin heterodimers have been implicated in neurodegeneration. Read more
A major factor in morbidity and mortality worldwide is end stage renal disease (ESRD). At least 10% of ESRD is caused by focal and segmental glomerulosclerosis (FSGS), a form of steroid resistant nephrotic syndrome. Read more
Myelin, a fatty insulating sheath enwrapping axons in the nervous system, plays a central role in regulating the viability and activity of neural circuits, thus it is an essential factor in every aspect of healthy brain function. Read more
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