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death PhD Projects, Programmes & Scholarships

We have 141 death PhD Projects, Programmes & Scholarships

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We have 141 death PhD Projects, Programmes & Scholarships

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Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins

Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more

Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy. Read more

Determining novel molecular regulators of necrosis controlling premature cell death

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

Institute of Cancer Sciences

 The Institute of Cancer Sciences is part of a national centre of excellence in the fight against cancer. We carry out a programme of world-class science directed at understanding the molecular changes that cause cancer. Read more

Using epigenetic modifiers in combination with 5-FU based chemotherapy to elicit tumour specific immune responses and immunogenic cell death in colorectal cancer.

HDAC inhibitors (HDACi) are an emergent class of epigenetic modifying agent (EMA), with multi-modal mechanisms-of-action in both tumour and tumour microenvironment (TME). This project aims to understand how these drugs modulate efficacy of 5-FU-based chemotherapy to counteract transcriptional plasticity and immune evasion that underpins emergence of treatment resistance. Read more

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