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We have 24 degeneration PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
degeneration PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 24 degeneration PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Brain tissue mechanics: constitutive modeling of degeneration and dynamics
The aim of this project is to evaluate the mechanics of grey and white matter found in the brain during health & disease and effective methods by which to model disease mechanics and progression. Read more
Modeling cartilage degeneration using imaging data
We have an exciting new PhD study funded by a Royal Society NZ Marsden grant. The study will reveal how subtle sub-micron scale collagen network changes, in early degeneration of soft tissues, may be related to macro length scale non-invasive tissue imaging using optical coherence tomography (OCT). Read more
Insights into eye disease: understanding the molecular basis of age-related macular degeneration
Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]). Read more
The role and regulation of microtubules during axon growth and degeneration
Axons are the enormously long cable-like processes of neurons that wire the nervous system. These delicate structures have to be maintained for a life time. Read more
Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment
The optic nerve is a special sensory nerve that transmits visual impulses from the retina to the brain. Primary Open Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin that affects 1 in 10 elderly individuals. Read more
Development of a gene activated construct targeting proinflammatory signalling to promote zonal regeneration of osteoarthritic cartilage
Current treatments fail to effectively repair cartilage and typically only delay the injury associated joint degeneration that leads to post-traumatic osteoarthritis (PT-OA). Read more
Effect of Post-traumatic OA on the morphological and biomechanical properties of the mouse knee joint
Musculoskeletal diseases have a huge impact in our ageing society, affecting dramatically the disability of patients suffering from them. Read more
Investigating novel therapeutic strategies for severe neurodegenerative disease
Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterised by degeneration of the longest motor neurons leading to muscle weakness and spasticity in the lower limbs. Read more
MScR - In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies
Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more
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α-synuclein aggregates in human biofluids as a biomarker for Parkinson's disease
Parkinson's disease (PD) is an age-related progressive neurodegenerative disorder, second most common after Alzheimer's disease. Read more
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PhD position - Retina research in the RETORNA MSCA consortium
In the framework of the Marie Skłodowska Curie Actions - Doctoral Networks (MSCA-DN) the Consortium of the project “Targeting RNA as an approach for treating… Read more
Development of long-acting injectable (LAI) drug delivery systems to treat ocular diseases
Delivery of drug molecules to treat visually impairing ocular diseases that originate in the posterior segment of the eye, has been the most challenging task to the pharmaceutical scientists and retinal specialists. Read more
Translational potential of novel mitochondrial-targeted nanoparticles encapsulating hydrogen sulphide as modulators of neurological disease.
Neurodegenerative disorders such as Parkinson’s disease occur due to the progressive and irreversible degeneration of nerve cells. Read more
The energetics of the osteochondral junction during non-equilibrium states of loading: beyond the surface – bone deep.
This project intends to evaluate the dynamics of articular cartilage. There are two key components. (i) evaluate energy transfer between articular cartilage and the subchondral bone in osteochondral cores. Read more
The effect of dementia and aging on the functional and hemodynamic response of the brain
The neuro-vascular unit and the hemodynamic response regulate how the blood supply in our brain meets the metabolic demand of neuronal activity. Read more
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