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degeneration PhD Projects, Programmes & Scholarships
We have 21 degeneration PhD Projects, Programmes & Scholarships
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Investigating the ability of circadian clocks to mitigate degeneration of the back of the eye
Circadian clocks are present in most tissues and cells throughout the body, and have a crucial role in health and disease. Removal of clock factors can cause dysfunction. Read more
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Development of novel treatments for age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of vision loss in Europe and the US. Current therapies for neovascular AMD consist of monthly intravitreal injections of anti-VEGF antibodies delivered over several years. Read more
The role and regulation of microtubules during axon growth and degeneration
Axons are the enormously long cable-like processes of neurons that wire the nervous system. These delicate structures have to be maintained for a life time. Read more
Insights into eye disease: understanding the molecular basis of age-related macular degeneration
Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]). Read more
Psychological intervention, cognitive training, functional rehabilitation and well-being in clinical populations with brain degeneration
The concept of human well-being is a fundamental aspect of our existence and is often particularly vulnerable upon diagnosis and/or progression of long-term neurological conditions for which there is no cure, such as Parkinson’s, Alzheimer’s and Huntington’s disease. Read more
Universal genome editing strategies for ataxia telangiectasia
Ataxia telangiectasia (A-T) is a severe autosomal recessive genetic disease caused by mutations in the ATM gene, which lead to cerebellar degeneration, cancer susceptibility and immunodeficiency. Read more
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Innovative Nanoformulations to Prevent Sight Loss Progression -NanoSight
Post summary. Age-related macular degeneration (AMD), the most common cause of blindness in patients over sixty, accounts for almost 10% of blindness worldwide. Read more
The role of dynamic changes in proteome in pancreatic cancer initiation
Introduction. Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate under 7%. Better understanding of PDAC formation will help improve this. Read more
Sustained Release Nanocarriers for Ocular Drug Delivery
Ophthalmic drug delivery remains the most challenging task to pharmaceutical scientists. This is due to the unique structure of the eye, which restricts the entry of drug molecules at the required site of action. Read more
Understanding the aetiology of diabetic neuropathy
Diabetic neuropathy is a common secondary complication of diabetes mellitus which affects around 50% of all patients with diabetes - impacting on health, wellbeing and quality of life. Read more
Development of micro-incubator OCT/ OCE bioreactor system to engineer a robust musculoskeletal tissue model
Achieving adequate musculoskeletal tissue healing is one of the most challenging factors in the repair of orthopaedic tissues. The problem of hard-to-soft tissue fixation is the major cause of failure of replacement grafts and leads to further musculoskeletal degeneration e.g. Read more
4-year PhD Studentship: Investigating the relationship and modelling the impact of neuroinflammation on cerebral vascular function in dementia using novel 3D models of the cerebral vasculature
Reduced blood flow and a breakdown of the protective blood-brain barrier (BBB) are major contributors to the development of cognitive decline and disease pathology in the early stages of dementia [1]. Read more
4-year PhD Studentship: Developing new synergistic therapies of bactericidal nanotopography and biophysical stimulation to combat AMR bacterial infections of implants
The recent WHO report (2019) on global antimicrobial resistance (AMR) highlights not only the growing issue of resistance, identifying it as one of the greatest threats we face as a global community, but also the lack of new effective options to tackle bacterial infections. Read more
RNA biology in neurons and neurodegeneration
For cells to perform their biological functions, they need to able to adopt specific shapes and form functionally distinct subcellular compartments. Read more
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