We have 81 differentiation PhD Projects, Programmes & Scholarships

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differentiation PhD Projects, Programmes & Scholarships

We have 81 differentiation PhD Projects, Programmes & Scholarships

Stochastic modelling and inference for live-cell gene expression time-series data to unravel the mechanisms of stem cell differentiation

  Research Group: Division of Statistics
This project will develop statistical methodology for noisy time-series data and stochastic computational models to analyse live-cell imaging data provided by the lab of our collaborator Dr Cerys Manning at the University of Manchester. Read more

Molecular modelling and analysis of plasma cell cancers

This fully funded PhD place provides an exciting opportunity to pursue postgraduate research relating to blood cell cancers, in particular plasma cell neoplasms such as multiple myeloma. Read more

Understanding the gene regulatory landscape of embryonic stem cells and cancer cells

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more

MSc by Research: Using genome editing to study the mechanisms of immune cell proliferation and differentiation

T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more

Epigenetic regulation of bivalent genes in development and cancer

Our groups are interested in identifying epigenetic mechanisms driving cancer progression. Although it is well known that cancer cells harbor many DNA mutations, they also have significant alterations of their epigenome. Read more

MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. Read more

Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

Uncovering the molecular mechanisms underlying spinal cord regeneration

About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have very poor capacities to regenerate, thus resulting in a permanent loss of function. Read more

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