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dna PhD Projects, Programmes & Scholarships
We have 350 dna PhD Projects, Programmes & Scholarships
Single-molecule investigation of how flap-endonucleases recognise and cleave DNA structures to allow DNA replication (S3.5-SMP-Sayers)
Replication of DNA is one of the most fundamental processes of life, and the molecular machinery required in this process are some of the most evolutionarily ancient and universally conserved. Read more
Combining simulations and microscopy to understand how DNA uses physics to do biology (S3.5-MPS-Harris)
While we have sequenced the genetic codes of over 3000 species, we are still far from understanding how this genetic information is controlled in even the simplest organisms. Read more
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MRC DiMeN Doctoral Training Partnership: Understanding how damaged DNA is excised and repaired to maintain genome integrity and prevent cancer.
Background. DNA is constantly damaged and must be repaired to prevent genome instability and cancer. Conversely chemotherapy typically induces DNA damage to cause cancer cell death. Read more
Studying how epigenetics controls DNA repair in neuronal cells
Background. Our DNA is under constant attack from a variety of DNA damaging agents, which pose a significant threat to development, neurological function, and organismal survival. Read more
How can DNA condensate despite its negative charge? Implications in genome regulation, antibiotic resistance and gene therapy.
DNA molecules repel each other due to their negative charge. However, in the presence of multivalent ions and some proteins, DNA can condensate into a highly compact structure. Read more
Looping DNA for nanotech and biomedicine using computer simulations
DNA is commonly pictured as a perfect double helix, although it is mechanically distorted inside our bodies. Inside cells, DNA loops and ‘supercoils’ (coils on itself) to facilitate the main genetic operations such as gene activation and genome replication. Read more
Phosphate triesters: Forgotten adducts of DNA damage or biomarkers for cancer? (S3.5-MPS-Williams)
Alkylating agents (AAs) are known mutagens and carcinogens for humans whose effects are largely due to the formation of alkyl adducts in DNA. Read more
Molecular Machines from Adapted Transcription Factor-DNA Complexes
Scientists are investing significant effort into developing small molecular machines capable of translational or rotational motion at the molecular level… Read more
Investigating how chromatin guides de novo DNA methylation
Research Group:
Institute of Cell Biology
DNA methylation is the most common epigenetic mark found in mammals and is associated with gene repression. It is catalysed by DNA methyltransferases (DNMTs) and dysregulation can cause developmental diseases and cancers. Read more
Redefining DNA-double strand break repair in humans
Numerous DNA damaging agents constantly cause damage to cellular DNA. Read more
EASTBIO: Location,location, location: DNA damage sensors which launch protective responses to DNA damage
DNA damage happens at very high frequency in the cells in our bodies – meaning that the instructions for the proper functioning of cells could be altered unless the mistakes are spotted and corrected. Read more
Location, location, location: DNA damage sensors which launch protective responses to DNA damage
DNA damage happens at very high frequency in the cells in our bodies – meaning that the instructions for the proper functioning of cells could be altered unless the mistakes are spotted and corrected. Read more
Redefining the molecular mechanism of DNA double-strand break repair in humans
DNA double-strand breaks (DSBs) describe a break across both strands of DNA. This type of DNA damage can be catastrophic for cell survival as if not repaired correctly can lead to deletions, translocation, cell death and cancer. Read more
EastBio: Investigating the role of Cas1 nuclease in DNA repair
Research Group:
Institute of Cell Biology
In the bacterium Escherichia coli, the Cas1 (YgbT) protein seems to link immunity, DNA repair and chromosome segregation. The protein is a component of the bacterial immunity mechanism called CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR associated proteins). Read more
Light-activated DNA nanomachinery
DNA is an ideal material for building nanomachinery. it is responsive to stimuli, biocompatible, and can be programmed to assemble into structures of specific sizes and shapes. Read more