Exploring the boundaries of the human acetylome
Dr S Cowley, Prof D Panne
5 May 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.
Exploiting druggability host spots in protein phosphatase targets
Dr L Tabernero, Prof D Procter, Dr S Butterworth
Applications accepted all year round
In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.