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dopamine PhD Projects, Programmes & Scholarships
We have 10 dopamine PhD Projects, Programmes & Scholarships
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A10 dopamine neurons: the missing link in cell therapeutics for Parkinson's disease?
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and degeneration of the nigral dopamine neurons is a key pathological feature of the condition. Read more
Identifying cognitive and biochemical changes underlying lifestyle risk factors for dementia
Research Group:
Pharmacology and Experimental Therapeutics
Dementia describes a group of age-associated conditions of which cognitive decline is a major feature. Alzheimer’s disease (AD) is the most common cause of dementia and is characterised by the onset of a gradual cognitive decline. Read more
SELF-FUNDING MSc BY RESEARCH PROJECT: Probing the projections of different types of dopamine neurons
What makes one neuron different from another? How can we define different “types” of cells? Are cell types important?. In Parkinson’s disease some dopamine neurons seem to be more vulnerable to neurodegeneration. Read more
Biological rhythms and the dopamine system in cognitive dysfunction
Research Group:
Pharmacology and Experimental Therapeutics
Psychiatric disorders such as schizophrenia are associated with metabolic syndrome, obesity and diabetes. Schizophrenia affects 1.1% of the population and although not the most common psychiatric condition it is arguably the most severe and debilitating. Read more
Creating microcarriers for improving the survival and integration of cells transplanted to the brain.
For neurodegenerative diseases such as Parkinson’s disease, where a specific cell type is lost, it is possible to consider replacing these cells to restore the lost function. Read more
Supramolecular sensors for neurotransmitters
Neurological diseases are a leading cause of disability worldwide. Neurotransmitters (e.g. dopamine) are key molecules in neuronal communication, making their detection and quantification vital for medical diagnostics and therapeutics. Read more
Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease
The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more
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Generating a computational model of dopaminergic networks and exploring the selective vulnerability of different neurons within this circuit to protein aggregates
This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. Read more
Identification of novel cortical interneuron regulators implicated in neuropsychiatric disorders
Despite representing only ~20% of the entire neuronal population in the neocortex, the GABAergic (Gamma-Aminobutyric Acid) inhibitory interneurons play a pivotal role in most cortical functions. Read more
Neurotransmitters, brain blood flow and functional brain imaging signals.r
The function of modulatory neurotransmitter systems such as serotonin, dopamine or acetylcholine are implicated in a wide range of brain diseases and are targeted by a wide range of therapeutic drugs. Read more
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