Ocular drug delivery presents one of the greatest challenges in pharmaceutical science, largely due to the eye’s unique anatomy, which limits drug permeation to the intended site of action. Read more
Self-assembling peptide-based hydrogels (SAPH) are composed of short peptide sequences, typically consisting of 5 to 20 amino acids, which undergo spontaneous self-assembly into three-dimensional networks under physiological conditions. Read more
Current clinical therapies often rely on intermittent drug administration, such as frequent oral tablets or injections, as seen in diabetes management. Read more
Soft tissue reconstruction is emerging as an important strategy to repair and replace diseased or damaged tissue that has been compromised due to tumour removal, injury, trauma, ageing, etc. Read more
The aim of this study is to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) in a series of related drug classes. Read more
Minimally invasive microneedles (MNs) offer unique opportunities to address current challenges in the effective management of ocular disorders, such as age-related macular degeneration and diabetic retinopathy. Read more
Ovarian cancer is one of the most lethal gynaecological malignancies, often diagnosed at advanced stages due to non-specific symptoms and a lack of early detection methods. Read more
Recent figures from Diabetes UK show that 4.3 million people in the UK are diagnosed with diabetes of whom approximately 90% have type 2 diabetes mellitus (T2DM) and another 2.4 million are at high risk of developing the T2DM. Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
The incidence of oral squamous cell carcinoma (OSCC) in the UK has risen by 60% in the last decade. Treatment for OSCC is surgery followed by radio- or intravenous chemotherapy with the latter having profound off-target toxicity. Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
Gram-negative bacterial species, including E. coli, are major causes of infectious diseases worldwide and account for all organisms in the “critical” category of the WHO list of antibiotic-resistant "priority pathogens". Read more
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