Delivery of drug molecules to treat visually impairing ocular diseases that originate in the posterior segment of the eye, has been the most challenging task to the pharmaceutical scientists and retinal specialists. Read more
Lipid nanocapsules (LNCs) are very interesting nanoformulations as they can be made by phase inversion technique (PIT), a scalable method with predictable particle size at the beginning of the preparation process. Read more
Repurposing drug screens with compounds that have already gained FDA approval can accelerate the identification of new therapies to treat an illness and in the cancer setting extend life or provide compassionate care. Read more
Growing antimicrobial resistance (AMR) is one of the major global challenges and it is often linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgeries and infections. Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
In-cell quantification of drug concentrations is fundamentally important to drug function, efficacy and toxicity, and for understanding and accurately predicting drug interactions and inter-subject variability in drug response (either on-target or off-target effects). Read more
Cochlear implants are implanted electronic hearing device designed to produce useful hearing sensations to persons with severe to profound nerve deafness by electrically stimulating nerves inside the inner ear. Read more
Funding providers: UKRI Match Funded with Industry (AstraZeneca). Subject areas: Applied Mathematics, Mathematical Biology, Computational Modelling. Read more
We invite applications from research students interested in learning and developing an understanding of deep learning-based solutions for drug design for cancer chemotherapy. Read more
While traditional, small molecule drugs continue to play a significant role due to their oral bioavailability, they also suffer from lower selectivity, frequently accompanied with side-effects. Read more
Proinflammatory cytokines have been reported to suppress certain drug metabolizing enzymes (e.g., CYP3A4) both in vitro and in vivo, whereas the evidence… Read more
Mucosal routes of drug administration offer numerous advantages including ease of application, non-invasive nature and sometimes possibility of targeting particular organs. Read more
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