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We have 66 drug design and development PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships



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drug design and development PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 66 drug design and development PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Chemical glycoengineering of therapeutic antibodies

Glycosylation is the most common posttranslational protein modification. Recombinant therapeutic glycoproteins (RTGs) such as monoclonal antibodies (mAbs) are decorated with complex glycans that determine not only their efficacy but also other critical parameters such as in vivo half-life, stability and antigenicity. Read more

Development of long-acting injectable (LAI) drug delivery systems to treat ocular diseases

Delivery of drug molecules to treat visually impairing ocular diseases that originate in the posterior segment of the eye, has been the most challenging task to the pharmaceutical scientists and retinal specialists. Read more

Enzyme-responsive peptide hydrogel as in situ forming long-acting drug delivery implants

One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more

Mechanistic design of effective pharmaceutical cocrystal formulations

It is estimated that more than 70 percent of the compounds in the pharmaceutical pipeline can be poorly water-soluble. Since solid drug forms must dissolve before absorption can occur, strategies to improve drug solubility and dissolution are a continuous need. Read more

Cancer Patients Digital Twins to Investigating disease fragmentation and its impact on drug response in AML trials

Not all patients respond equally to the same treatments. This project aims to explore if there are clues in a patient’s genome that can predict how they will respond to different treatments and are there common genomic signatures that will influence response to chemotherapy. Read more

Production of super small nanocrystals for drug delivery to target tissues

The student will be involved in an exciting project related to the design, formulation and in vitro/in vivo characterisation of super small drug nanocrystals with specific surface properties to enhance drug accumulation in target tissues, such as the lymphatic or central nervous systems. Read more

Novel design and formulation strategies to enhance drug delivery

The main research activities of my research group concern the improvement of traditional drug formulation and the development of novel drug and formulation strategies to enhance bioavailability and patient acceptability. Read more

Towards the development of a novel class of broad-spectrum anti-infective drugs

Through exceptionally strong research collaborations at the interface of chemistry, biology, and medicine, we have applied innovative thinking to the field of (Minor Groove Binders) MGBs to develop a novel platform for drug discovery with the potential to treat an impressive range of diseases, including bacterial, fungal, parasitic, and viral infections. Read more

Development and Application of Enabling Methods for Drug Discovery

Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with molecular and temporal resolution. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

Predicting drug solubility in different solvents using molecular simulation and machine learning

Predicting the solubility of complex drug-like molecules is crucial at several stages of the drug discovery and manufacture. In particular, solvent selection has been highlighted as a crucial step in process design and optimisation [1]. Read more

Small molecule cancer drug discovery targeting resistant disease.

Despite continuous advances in targeted cancer therapy in recent years, there remains a major challenge to combat drug resistance and poor levels of efficacy in areas of unmet medical need. Read more

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