We have 104 drug discovery PhD Projects, Programmes & Scholarships

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drug discovery PhD Projects, Programmes & Scholarships

We have 104 drug discovery PhD Projects, Programmes & Scholarships

Unlocking intractable drug targets through rational discovery of Molecular Glue Degraders

The majority of high-value drug targets lack a conventional druggable active site and are considered intractable to traditional small molecule drugs (also termed ‘undruggable’), leading to massive investment in alternative drug modalities. Read more

Small molecule cancer drug discovery targeting resistant disease.

Despite continuous advances in targeted cancer therapy in recent years, there remains a major challenge to combat drug resistance and poor levels of efficacy in areas of unmet medical need. Read more

Pharmacokinetics Guided Natural Products Exploration for Drug Discovery, Development, Delivery and Therapy

  Research Group: Institute of Cancer Therapeutics
Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Read more

Developing Enabling Synthetic Methods for Accelerated Peptidomimetic Drug Discovery

Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with molecular and temporal resolution. Read more

Photoredox molecular editing for enhanced drug discovery

Molecular editing platforms, the process by which single atoms can be inserted or deleted selectively in or around a molecule’s skeleton, are transformative to synthetic chemists across industry and academia for the streamlined development of new drugs. Read more

Structural and Mechanistic Chemical Biology of Degraders Mode of Actions

Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more

Transcriptome biomarkers and mechanisms of chemoresistance

Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more

Towards the development of a novel class of broad-spectrum anti-infective drugs

Through exceptionally strong research collaborations at the interface of chemistry, biology, and medicine, we have applied innovative thinking to the field of (Minor Groove Binders) MGBs to develop a novel platform for drug discovery with the potential to treat an impressive range of diseases, including bacterial, fungal, parasitic, and viral infections. Read more

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