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We have 26 drug metabolism PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
drug metabolism PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 26 drug metabolism PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Impact of sex steroid metabolism and action on immune function in rheumatoid arthritis
This PhD opportunity will focus on the role of sex steroids (androgens and oestrogens) on the immune function in patients with rheumatoid arthritis. Read more
Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
Research Group:
Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
Evaluation of cardiac safety features of over-the-counter medications
It is now well-established that a number of prescription medications are linked to a low, but significant risk of alterations to the QT interval of the electrocardiogram and with an associated dangerous arrhythmia called torsades de pointes. Read more
Self Funded PhD Project: Studies on the Design, Synthesis and Biological Evaluation of a Novel Bioactive Indane Scaffold
A wide range of bioactive indane based scaffolds are employed clinically as treatment of many disease states, including inflammatory [1], cancer [2] and neurological conditions [3] and also in the treatment of HIV [4]. Read more
Identifying and validating novel drug targets related to metabolism in pathogenic fungi
Pathogenic fungi are responsible for illness and death across the globe. Diseases are caused by known, remerging and new fungal pathogens, highlighting the need for advancing therapeutics. Read more
Long non-coding RNA NEAT1 isoforms in the regulation of cellular glucose metabolism downstream TDP-43 dysfunction in ALS
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease caused by motor neuron loss that currently has no cure or a disease-modifying treatment. Read more
Cancer: Inhibiting cell metabolism to enhance tumour cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Application of advanced analytical methods to study key aspects of health and disease
Considerable advances in the analytical capabilities of modern techniques afford a new horizon in the study of health and disease. Read more
How does the human fungal pathogen, Candida albicans, exploit its metabolic flexibility to enhance its virulence?
Project offered for Ker Memorial PhD Studnetship in Infectious Diseases. Fungal pathogens kill over a million people every year. The most common human fungal pathogen is Candida albicans, a WHO-priority target. Read more
Haematology: Oncogenic reprogramming of immune cells
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more
Investigation and Characterisation of Cytochrome P450 enzymes in Mycobacteria Species
Mycobacteria are important pathogens in humans and other animals, and include Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Read more
Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Deconvoluting the spatial multi-omic landscape of high-grade glioma to target post-surgical residual disease
Background. High-grade gliomas are the most common cancers arising within the brain and contribute to ~190,000 brain tumour related deaths/year globally. Read more
Structural elucidation of small molecules using tandem mass spectrometry and accurately predicted fragmentation patterns
Applications are invited for a 4-year PhD studentship funded by an EPSRC industrial CASE award, commencing October 2023 for the project entitled. Read more
Unravelling the role of P4HB in skeletal development: towards treatment of heritable bone fragility
Osteogenesis Imperfecta (OI) affects 1 in 15-20,000 live births and results in a childhood with frequent fractures, reduced mobility and joint problems. Read more
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