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drug metabolism PhD Projects, Programmes & Scholarships

We have 27 drug metabolism PhD Projects, Programmes & Scholarships

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We have 27 drug metabolism PhD Projects, Programmes & Scholarships

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Polmorphisms in cytosolic drug metabolising enzymes: a combined proteomics and modelling approach to clinical impact

Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs). Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Development of antibody-drug conjugates (ADCs) for oncology indications

  Research Group: Institute of Cancer Therapeutics
A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells but are not harmful to normal tissue. Read more

Exploiting metabolic vulnerabilities induced by dietary restriction as novel therapies for infant leukaemia

TO APPLY, CLICK 'INSTITUTION WEBSITE'. Infant leukaemia is an aggressive malignancy with cure rates of less than 50%. Importantly, despite large international trials, there has been no improvement in survival over the last 2 decades. Read more

Laser Spectrometry Development for Isotopic Analysis in Environmental and Medical Applications

Summary. This is a fully-funded PhD opportunity based at NPL (London) that will investigate and establish laser spectrometry for measurement of stable isotope ratios and radiocarbon in carbon dioxide and methane, relevant for environmental monitoring and drug discovery applications. Read more

Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in human cells

There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD) but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD. Read more

Deciphering the role of white and brown adipocytes in metabolic disease

Our work focuses on understanding how obesity drives the development of type 2 diabetes and cardiovascular disease. Specifically, it aims to decipher molecular determinants of adipocyte number and distribution within the body; key factors of susceptibility to obesity-associated cardiometabolic diseases. Read more

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