Profiling drug metabolism activities in cancer models to identify metabolic activators of prodrugs and guide model system selection in anticancer (pro)drug discovery

Research Group: Institute of Cancer Therapeutics

Chemotherapy is a widely-used treatment for cancers, but is limited by a wide range of serious side effects, which have significant impacts on patient quality of life. Read more

Supervisors: Dr HJ Jones, Dr S Shnyder, Dr V Jha, Dr H Sheldrake

Year round applications PhD Research Project Self-Funded PhD Students Only

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Unravelling the Gut Microbiome's Role in Epilepsy with Obesity using a Rodent Model

Monash University Malaysia

School of Medicine and Health Sciences

The gut microbiota plays a crucial role in governing digestion, energy absorption and drug metabolism, where even the metabolites of the gut microbiota, such as short fatty acid chains, can influence seizure activity through the gut-brain axis via interaction with the inflammatory pathway. Read more

Supervisors: Assoc Prof Vinod Balasubramaniam, Dr Alina Arulsamy, Assoc Prof Amutha Ramadas

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The Development of Implantable Anti-tumour Devices for Enhanced Efficacy of Repurposed Drugs Using Advanced Manufacturing

Queen’s University Belfast

School of Pharmacy

Drug repurposing or repositioning, which investigates new indications for approved drugs, has always been a core approach in drug development, with approximately 30-40% of new drugs and biologics approved by the US FDA between 2007 and 2009 being repurposed or repositioned products (DOI. Read more

Supervisors: Prof G Andrews, Dr S Li, Prof D Jones

Year round applications PhD Research Project Self-Funded PhD Students Only

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Developing targeted treatments for HNRNPU-related neurodevelopmental disorder using drug repurposing strategies

University of Sheffield

School of Medicine and Population Health

Project Title. Developing targeted treatments for HNRNPU-related neurodevelopmental disorder using drug repurposing strategies. Read more

Supervisors: Prof M Balasubramanian, Prof S A Wilson

Year round applications PhD Research Project Self-Funded PhD Students Only

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PhD Opportunity - Investigating the role of autophagy and mitochondrial function in leukaemic stem cells

University of Glasgow

College of Medical, Veterinary and Life Sciences

'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Our lab is interested in biological processes that contribute to drug resistance in myeloid leukaemias, with particular focus on leukaemic stem cells (LSCs). Read more

Supervisors: Dr V Helgason, Dr EK Kalkman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Developing a platform for conformational sensing of gut hormones in diagnosis and drug discovery

Imperial College London

Department of Metabolism, Digestion & Reproduction

Gut-derived peptide hormones regulate a large number of important metabolic processes, and there is great interest in exploiting their effects to treat disease. Read more

Supervisor: Dr B Jones

31 March 2025 PhD Research Project Funded PhD Project (UK Students Only)

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Studying biological variation in the environmental sensor and novel psoriasis drug target Aryl Hydrocarbon Receptor (AHR): expression, regulation and biomarker potential

King’s College London

Faculty of Life Sciences & Medicine

Start date. 1st June 2025. Application deadline. 23rd March 2025. Interview date. from 10th April 2025. Psoriasis is an immune-mediated, chronic inflammatory skin condition due to combination of genetic predisposition, environmental triggers, and dysregulated innate and adaptive immune responses [1]. Read more

Supervisor: Dr P Di Meglio

23 March 2025 PhD Research Project Funded PhD Project (UK Students Only)

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BBSRC North East England BBSRC Doctoral Landscape

Newcastle University

North East England Doctoral Landscape (NEEDL) is a BBSRC-funded strategic Partnership in Biosciences doctoral training between four universities based in the North East of England, Durham University, Newcastle University, Northumbria University and Teesside University. Read more

Funded PhD Programme (Students Worldwide) BBSRC Doctoral Training Partnership

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Cardiac and skeletal muscle progenitor cells - driving regeneration ability by tryptophan metabolites

University of Leeds

Faculty of Biological Sciences

The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisors: Dr A.J. Smith, Dr T.S. Bowen

Year round applications PhD Research Project Self-Funded PhD Students Only

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Microfluidic Encapsulation of biologics into Nanomedicines

Queen’s University Belfast

School of Pharmacy

Progress in drug design has led to the development of new peptides, proteins, and drug molecules. However, the limited ability to deliver selectively these molecules at well-defined dosing regimens and without invoking drug-resistance remains a significant challenge. Read more

Supervisor: Prof D Lamprou

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 31 drug metabolism PhD Projects, Programmes & Scholarships

drug metabolism PhD Projects, Programmes & Scholarships

We have 31 drug metabolism PhD Projects, Programmes & Scholarships

Profiling drug metabolism activities in cancer models to identify metabolic activators of prodrugs and guide model system selection in anticancer (pro)drug discovery

Drug metabolism - prediction, detection, and isolation

Metabolic Processes Driving Fatty Liver Disease and Drug Hepatotoxicity

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

PHD BIOLOGICAL SCIENCES

Mutations in anaerobic mixed communities

Unravelling the Gut Microbiome's Role in Epilepsy with Obesity using a Rodent Model

The Development of Implantable Anti-tumour Devices for Enhanced Efficacy of Repurposed Drugs Using Advanced Manufacturing

Developing targeted treatments for HNRNPU-related neurodevelopmental disorder using drug repurposing strategies

PhD Opportunity - Investigating the role of autophagy and mitochondrial function in leukaemic stem cells

Developing a platform for conformational sensing of gut hormones in diagnosis and drug discovery

Studying biological variation in the environmental sensor and novel psoriasis drug target Aryl Hydrocarbon Receptor (AHR): expression, regulation and biomarker potential

BBSRC North East England BBSRC Doctoral Landscape

Cardiac and skeletal muscle progenitor cells - driving regeneration ability by tryptophan metabolites

Microfluidic Encapsulation of biologics into Nanomedicines

We have 31 drug metabolism PhD Projects, Programmes & Scholarships

drug metabolism PhD Projects, Programmes & Scholarships

We have 31 drug metabolism PhD Projects, Programmes & Scholarships

Profiling drug metabolism activities in cancer models to identify metabolic activators of prodrugs and guide model system selection in anticancer (pro)drug discovery

Drug metabolism - prediction, detection, and isolation

Metabolic Processes Driving Fatty Liver Disease and Drug Hepatotoxicity

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

PHD BIOLOGICAL SCIENCES

Mutations in anaerobic mixed communities

Unravelling the Gut Microbiome's Role in Epilepsy with Obesity using a Rodent Model

The Development of Implantable Anti-tumour Devices for Enhanced Efficacy of Repurposed Drugs Using Advanced Manufacturing

Developing targeted treatments for HNRNPU-related neurodevelopmental disorder using drug repurposing strategies

PhD Opportunity - Investigating the role of autophagy and mitochondrial function in leukaemic stem cells

Developing a platform for conformational sensing of gut hormones in diagnosis and drug discovery

Studying biological variation in the environmental sensor and novel psoriasis drug target Aryl Hydrocarbon Receptor (AHR): expression, regulation and biomarker potential

BBSRC North East England BBSRC Doctoral Landscape

Cardiac and skeletal muscle progenitor cells - driving regeneration ability by tryptophan metabolites

Microfluidic Encapsulation of biologics into Nanomedicines

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