drug safety PhD Projects, Programmes & Scholarships

We have 28 drug safety PhD Projects, Programmes & Scholarships

MRC DiMeN Doctoral Training Partnership: Application of advanced laboratory skin models to development of novel therapeutics for severe skin-blistering adverse drug reactions

University of Liverpool MRC DiMeN Doctoral Training Partnership

Severe skin-blistering adverse drug reactions, such as Stevens-Johnson syndrome (SJS) have a very high mortality rate and can have devastating life-long consequences for survivors, including loss of vision and psychological effects. Read more

Supervisors: Dr D Carr, Prof D Naisbitt, Prof A Dickinson

17 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Evaluation of cardiac safety features of over-the-counter medications

University of Bristol School of Physiology, Pharmacology & Neuroscience

It is now well-established that a number of prescription medications are linked to a low, but significant risk of alterations to the QT interval of the electrocardiogram and with an associated dangerous arrhythmia called torsades de pointes. Read more

Supervisor: Prof J C Hancox

Year round applications PhD Research Project Self-Funded PhD Students Only

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Precision Medicine DTP - AI-driven drug discovery for diseases of unmet need with high-throughput phenomics data

University of Edinburgh School of Informatics

Abstract. Drug discovery is extremely expensive and most candidate compounds fail at various stages of clinical trials. Artificial Intelligence (AI) has recently emerged as a promising tool to accelerate the search for new active compounds. Read more

Supervisors: Dr D Oyarzun, Prof N Carragher, Dr A Unciti-Broceta

15 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Molecular characterisation of a novel transporter for the atypical antipsychotic clozapine

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Schizophrenia is a severe psychiatric illness affecting about 24 million people worldwide. Schizophrenia can have a devastating effect on a patient’s life and is associated with increased mortality, with life expectancy reduced on average by 15 years compared to that of the general population. Read more

Supervisors: Dr D Dickens, Prof M Pirmohamed

Year round applications PhD Research Project Self-Funded PhD Students Only

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Unlocking Insights from Real-World Evidence: Exploring the Safety of Drug Combinations (NDORMS 2024/2)

University of Oxford Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences

Adverse drug reactions (ADRs) are unintended, harmful events attributed to the use of medicines. In modern healthcare, ADRs pose a significant challenge due to the complexity of therapeutics, an aging population, and rising multimorbidity. Read more

Supervisors: Dr E Burn, Dr D Newby, Dr A Jödicke, Dr A Prats-Uribe, Prof D Prieto-Alhambra

1 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Subgroup effects in antihypertensive and type 2 diabetes drug classes: a comparative effectiveness and safety study integrating real-world and genetic data

University of Oxford Division of Medical Sciences

Commercial partner: Janssen. Pharmaceutical Companies of Johnson & Johnson. Estimating subgroup treatment effects from clinical trials is notably difficult due to the limited sample size and under-representation of patients with multimorbidity. Read more

Supervisors: Prof D Prieto-Alhambra, Dr M Català Sabaté

1 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Identifying new drug targets within Mycobacterium tuberculosis

University of Warwick School of Life Sciences

Tuberculosis (TB) is the leading cause of death worldwide and reflects a serious global health challenge. This bacterial pathogen kills more people than malaria and HIV combined, and is increasingly developing resistance to many of the current front-line drugs. Read more

Supervisor: Dr P Stansfeld

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Combining laser and ultrasound based molecular delivery strategies for enhanced drug delivery

University of Dundee School of Science and Engineering

Overview. This project addresses the critical area of delivering therapeutics to the skin. If successful, the approach will have direct and positive consequences for the treatment of a range of skin diseases, but may also be viewed as a more generic means of drug delivery for treating a much wider range of disease. Read more

Supervisors: Dr P Campbell, Dr R Hickerson

28 February 2024 PhD Research Project Self-Funded PhD Students Only

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(BBSRC DTP) Peptide hydrogels for delivery of therapeutics for ophthalmic applications

The University of Manchester Department of Chemistry

"Wet" macular degeneration and related retinal diseases are a leading cause of sight loss, impacting 570,000 people in UK and at least 96M worldwide. Read more

Supervisors: Prof A Miller, Prof T Aslam, Dr A Saiani

19 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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A systematic screening tool for nanocarrier design and efficient drug delivery against biological barriers.

Queen’s University Belfast School of Pharmacy

Encapsulation of APIs in a liposome can dramatically alter the distribution by controlling the release to normal tissue while facilitating the accumulation to the site of inflammation. Read more

Supervisor: Dr J Tian

Year round applications PhD Research Project Self-Funded PhD Students Only

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Innovative chemical modification of antimicrobial peptides; enhancing bioactivity and investigating mode of action

Nottingham Trent University School of Science & Technology

Project ID. SST_SHiMR_15. In 2014 the O’Neill report estimated that unless urgent action is taken, deaths caused by antimicrobial resistant (AMR) infections will raise to 10 million annually by 2050, surpassing cancer as the greatest single cause of death due to disease. Read more

Supervisor: Dr W Cross

12 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Modification of antibiotics to improve efficacy / safety

Kingston University Faculty of Health, Science, Social Care and Education

With increasing concern over antibiotic resistance, antibacterial agents such as chloramphenicol and colistin, which have frequently been passed over in the past because of concerns over toxicity, are now becoming more important to tackle resistant bacterial strains. . Read more

Supervisor: Dr I Beadham

Year round applications PhD Research Project Self-Funded PhD Students Only

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Designs for sequences of early phase (modular) studies

University of Cambridge MRC Biostatistics Unit

Background to the project. An emerging setting is to conduct a trial of an experimental drug as monotherapy, then in combination(s) with previously studied agents, and then to proceed into expansion cohorts (called modular trials). Read more

Supervisor: Dr PM Mozgunov

15 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Optimising deep brain stimulation for treatment of epilepsy: a networks based approach

University College London UCL-Birkbeck MRC DTP

This PhD provides the opportunity to work with clinicians and scientists from GOS Institute of Child Health and a UK based biotechnology SME, Amber therapeutics, to develop deep brain stimulation (DBS) techniques for the treatment of childhood epilepsy. Read more

Supervisors: Prof T Baldeweg, Mr M Tisdall

8 January 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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The development of new antiviral agents targeting HIV-1

Newcastle University Faculty of Medical Sciences Graduate School

Even before the current global COVID-19 pandemic, the threat posed to human health by viruses was extensive and although significant progress in targeting some viruses (e.g., HIV-1 and hepatitis C) has been made, challenges remain. Read more

Supervisor: Dr M Ashton

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 28 drug safety PhD Projects, Programmes & Scholarships

drug safety PhD Projects, Programmes & Scholarships

We have 28 drug safety PhD Projects, Programmes & Scholarships

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