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drug design PhD Projects, Programs & Scholarships

We have 91 drug design PhD Projects, Programs & Scholarships

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  (BBSRC DTP) Inhibition of SR protein kinase 1 with designer peptides
  Dr A Golovanov, Dr A Almond
Application Deadline: 31 January 2019
This PhD project addresses BBSRC’s ENWW in that the student will be trained in. Biophysical techniques - ITC, SPR, CD; Structural biology techniques - solution state NMR and X-ray crystallography; Computational techniques - molecular dynamics simulations and computer modelling and analysis.
  Structure guided inhibitors design of human Mitochondrial Thymidine Kinase (TK2)
  Dr Y Jin
Application Deadline: 15 March 2019
Background. Mitochondrial Thymidine Kinase 2 (TK2) catalyses transfer of a γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine, deoxycytidine, or deoxyuridine to form their 5’-mono-phosphates.
  Computer-aided molecular design: improved ligand docking using electronic structure and molecular dynamics simulations
  Dr R A Bryce, Dr N Burton
Applications accepted all year round
In structure-based drug design, computational modelling techniques are frequently used to predict the orientation and affinity with which a ligand binds to its protein receptor.
  In vitro assessment of drug sequestration into lysosomes and in silico prediction of implications for drug disposition and therapeutic efficacy
  Dr A Galetin, Dr D Hallifax
Applications accepted all year round
Intracellular concentration of a drug is an important determinant of its efficacy, toxicity, and potential drug-drug interactions [1].
  PhD Studentship – Free energy calculations in drug discovery
  Prof J W Essex, Prof J G Frey
Applications accepted all year round
Protein-ligand binding free energy is a crucial property used in the discovery and optimisation of novel drugs.
  Novel cyclic peptide constructs for targeted biomolecular imaging
  Prof M Zanda, Dr S Butler
Application Deadline: 15 February 2019
Over 40 cyclic peptides are used in the clinic for a wide range of applications, such as somatostatin and ciclosporin. Cyclic peptides have enormous potential for disrupting protein-protein interactions and are therefore being pursued as drug candidates for treating a number of unmet medical needs.
  Exploiting druggability host spots in protein phosphatase targets
  Dr L Tabernero, Prof D Procter, Dr S Butterworth
Applications accepted all year round
In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.
  Novel assays for screening drug – lipid membrane interactions
  Dr G Shearman, Prof R Singer
Applications accepted all year round
Small molecule therapeutics represent a major contributor to human health and wellbeing both in developed and developing economies.
  Deep Learning / Bioinformatics Approach for Protein-Protein Interaction Prediction
  Dr JC Nebel
Applications accepted all year round
Since most molecular processes rely on protein–protein interactions PPIs), knowledge of those interactions is extremely valuable for biomedical research and drug design.
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