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drugs PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 211 drugs PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Predicting efficacy and safety of drugs using genetic and population data

A major factor influencing the cost of drugs is the high rate of failure during clinical trials due to inefficacy (failure to have the desired effect) or safety issues (adverse effects). Read more

Enzyme-responsive peptide hydrogel as in situ forming long-acting drug delivery implants

One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more

Investigation into the in-vitro lung deposition of liposomal formulations of the dual fixed-dose combination inhaler

  Research Group: Medicines Development and Pharmaceutical Sciences
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are diseases associated with the airflow in the lungs (WHO, 2013). Inhalation is the most effective route of administration for treating asthma and COPD (Labiris and Dolovich, 2003). Read more

Broadening the spectrum of antibacterial drugs to tackle multi-drug resistant Gram-negative pathogens

  Research Group: Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to average human lifespan. Read more

Psychedelic drugs and serotonergic modulation of functional connectivity in cortical microcircuits

Psychoactive drugs result in profound alterations of our state of consciousness. Well known examples of such drugs are general anaesthetics, in use since mid-19th century, and psychedelics, which are consumed from times immemorial. Read more

Advanced manufacturing of paediatric formulations with poorly water soluble drugs

This project employs an advanced manufacturing technique, microwave-induced in situ amorphization, in combination with a wide range of characterization techniques to tackle the consistent stability issue of amorphous solid dispersions as a means of improving the dissolution performance of paediatric personalised formulations with poorly water soluble drugs. Read more

Formulation of poorly-soluble drugs

Poorly water-soluble drugs is an important class of pharmaceutical compounds that are finding numerous applications for the therapy of different pathological conditions. Read more
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Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

Cancer: Repurposing drugs as new treatments for breast cancer

Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more

Evaluation of cardiac safety features of over-the-counter medications

It is now well-established that a number of prescription medications are linked to a low, but significant risk of alterations to the QT interval of the electrocardiogram and with an associated dangerous arrhythmia called torsades de pointes. Read more

Cancer: Epigenetic therapy using microbubble-mediated drug delivery for colorectal cancer

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (including DNA methyltransferase inhibitors, HDAC inhibitors and/or vitamin C), as a potential combination therapy for colorectal cancer (CRC). Read more

Sustainable and controlled drug delivery to fight global antimicrobial resistance (AMR) using hybrid porous nano containers

  Research Group: Chemistry and Biosciences
Growing antimicrobial resistance (AMR) is one of the major global challenges and it is often linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgeries and infections. Read more

Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more

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