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We have 211 drugs PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
drugs PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 211 drugs PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Predicting efficacy and safety of drugs using genetic and population data
A major factor influencing the cost of drugs is the high rate of failure during clinical trials due to inefficacy (failure to have the desired effect) or safety issues (adverse effects). Read more
Enzyme-responsive peptide hydrogel as in situ forming long-acting drug delivery implants
One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more
Investigation into the in-vitro lung deposition of liposomal formulations of the dual fixed-dose combination inhaler
Research Group:
Medicines Development and Pharmaceutical Sciences
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are diseases associated with the airflow in the lungs (WHO, 2013). Inhalation is the most effective route of administration for treating asthma and COPD (Labiris and Dolovich, 2003). Read more
Broadening the spectrum of antibacterial drugs to tackle multi-drug resistant Gram-negative pathogens
Research Group:
Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to average human lifespan. Read more
Psychedelic drugs and serotonergic modulation of functional connectivity in cortical microcircuits
Psychoactive drugs result in profound alterations of our state of consciousness. Well known examples of such drugs are general anaesthetics, in use since mid-19th century, and psychedelics, which are consumed from times immemorial. Read more
Advanced manufacturing of paediatric formulations with poorly water soluble drugs
This project employs an advanced manufacturing technique, microwave-induced in situ amorphization, in combination with a wide range of characterization techniques to tackle the consistent stability issue of amorphous solid dispersions as a means of improving the dissolution performance of paediatric personalised formulations with poorly water soluble drugs. Read more
Formulation of poorly-soluble drugs
Poorly water-soluble drugs is an important class of pharmaceutical compounds that are finding numerous applications for the therapy of different pathological conditions. Read more
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Discovering off-target side-effects and drug repurposing candidates using expression perturbation data
The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more
Deep learning enabled alternative drug design for cancer patients
We invite applications from research students interested in learning and developing an understanding of deep learning-based solutions for drug design for cancer chemotherapy. Read more
Cancer: Repurposing drugs as new treatments for breast cancer
Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more
Experimental and computational investigation of the stabilisation of drug molecules in their amorphous state by mesoporous polymers
The formulation and delivery of poorly soluble drugs has always been a challenge with estimated 70-90% of molecules in the development pipeline suffering from poor solubility and bioavailability. Read more
Evaluation of cardiac safety features of over-the-counter medications
It is now well-established that a number of prescription medications are linked to a low, but significant risk of alterations to the QT interval of the electrocardiogram and with an associated dangerous arrhythmia called torsades de pointes. Read more
Cancer: Epigenetic therapy using microbubble-mediated drug delivery for colorectal cancer
The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (including DNA methyltransferase inhibitors, HDAC inhibitors and/or vitamin C), as a potential combination therapy for colorectal cancer (CRC). Read more
Sustainable and controlled drug delivery to fight global antimicrobial resistance (AMR) using hybrid porous nano containers
Research Group:
Chemistry and Biosciences
Growing antimicrobial resistance (AMR) is one of the major global challenges and it is often linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgeries and infections. Read more
Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides
The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more