Defining how cancer cells acquire resistance to microtubule-based drugs
Institute of Cell Biology
Dr J Welburn, Dr N Carragher
13 December 2018
Taxol (paclitaxel) is a major drug used in the treatment of solid cancers (breast, lung, ovarian, bladder). However, resistance to taxol arises regularly and thus it is critical to find ways to circumvent this resistance.
Chemical modulation of cellular redox balance for cancer treatment
Dr I Romero-Canelon
Applications accepted all year round
Platinum complexes, cisplatin, oxaliplatin and carboplatin, are the most widely used anticancer drugs. However, these DNA-targeting treatments are a low selectivity approach with deleterious consequences and a high incidence of resistance.