The adult heart is a highly complex organ that develops through the remodelling of a simple linear tube at very early stages of embryonic development. Read more
The three retinoic acid receptors (RAR), RARα, RARβ, RARɣ, are transcription factors that control gene expression and cell fate following their activation by all-trans retinoic acid (ATRA), the active metabolite of vitamin A. Read more
A 2025 Crick PhD project with Nate Goehring. Arguably, the central challenge in developmental biology is to understand how the enormous diversity of cell form, fate, and function that is typical of multicellular organisms arises from a single fertilized egg. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Outline. Self-renewal and pluripotency are the main characteristics of embryonic stem cells (ESCs). Read more
Ubiquitination is a fundamental post-translational modification (PTM), which profoundly impacts diverse cellular functions, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune response. . Read more
The Bioengineering Node at Durham University is growing its activities and seeking the appointment of three (n3) exceptional students for fully funded PhD studentships, to work on cutting-edge projects in the areas of cardiovascular mechanics and biological fluid mechanics. Read more
This PhD project offers a unique and exciting opportunity to investigate the effects of microplastics and nanoplastics (MNPs) exposure on bovine oocyte developmental competence, a critical determinant for successful fertilization and early embryonic development. Read more
During early embryogenesis, segments (somites) are formed during a process called somitogenesis. These somites will go on to form the bones and muscles of the skeleton. Read more
The 46th chromosome in XX female mammals, the second X, has to be switched off. That way females equalize gene dosage of X-linked genes with XY males. Read more
Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more
Epidemiological evidence in humans indicates that acute heat exposure around the time of mating results in pregnancy loss, with potential long-term consequences on the offspring. Read more
Melanoma is the most deadly form of skin cancer, with incidence rates rising by 140% in the UK since the 1990s and continuing to increase globally. Read more
Efforts have been made to create guidelines [1] and standards [2] to improve the quality of the fNIRS experimentation and of the fNIRS research in general. Read more
Meiosis is a specialised type of cell division that produces haploid daughter cells known as gametes that are important for sexual reproduction. Read more
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