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We have 32 embryonic PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
embryonic PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 32 embryonic PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Regulation of gene expression by the maternal contribution of modified RNAs during embryonic development (AKAY_U23DTPR)
Germline stem cells are essential for the survival of organisms by giving rise to offspring. Gene expression changes within the germ cells can affect embryonic development, and in some organisms, such changes are transgenerationally inherited. Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
The role of the spliceosome protein Prpf8 in embryonic development
Errors that occur during cardiac development cause congenital heart defects (CHD). Despite the prevalence of CHD, the developmental processes that ensure the heart forms correctly are still being elucidated. Read more
MSc by Research: Understanding the beginning of life: the role of non-canonical ubiquitylation in early embryonic development
Ubiquitin is a small, yet influential, protein that is attached to other substrates to control their stability or activity in a process called ubiquitylation. Read more
Dissecting the role of novel haematopoietic factors in development and disease
Blood is made up of different cell types with different functions, such as carrying oxygen (red blood cells), help with wound healing (platelets) and fighting infections (white blood cells). Read more
MSc by Research: Does CDK1 regulate NICD turnover in a cell cycle dependant manner in Drosophila Melanogaster?
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life, including cell fate specification within progenitors. Read more
Fully funded PhD in Neuroscience: Characterisation of cortical neural precursor cell defects in DLG2-/- Human Brain Organoids
Title of the project. Characterisation of Cortical Neural Precursor Cell Defects in DLG2-/- Human Brain Organoids. Project Summary. Read more
Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
Identifying novel regulators of haematopoiesis using flies
Supervisors. Iwan Evans (primary supervisor); Steve Brown (Biosciences, secondary supervisor). Project details. Control of blood cell proliferation, survival and activation is critical to the health of an organism. Read more
Novel functions of the hydroxylase and arginine demethylase JMJD6.
JMJD6 is a member of the jumonji domain-containing (JmjC) protein family. These proteins are metalloenzymes that can catalyse hydroxylation and demethylation on DNA, RNA and protein substrates. Read more
(EPSRC DTP) Investigating the biological impact of PLA nanoplastics interacting with environmental pollutant
Non-biodegradable plastics that fragment under environmental conditions into incidental micro/nano plastics (MNPLs), are ubiquitous in the environment. Read more
Deciphering a novel anti-ageing epigenetic programme
Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation. Read more
Cell-biological mechanisms mediating primary cilium mediated interpretation of Shh signalling during vertebrate neuronal differentiation
Newborn neurons undergo extensive morphological changes as they polarise to extend axons. In the developing spinal cord, newborn neurons extend axons towards their targets in response to cues from the surrounding tissues. Read more
Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1
RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RAC1-NDD) that results from mutations in the RAC1 gene. Read more