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embryonic PhD Projects, Programmes & Scholarships
We have 36 embryonic PhD Projects, Programmes & Scholarships
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The role of the spliceosome protein Prpf8 in embryonic development
Errors that occur during cardiac development cause congenital heart defects (CHD). Despite the prevalence of CHD, the developmental processes that ensure the heart forms correctly are still being elucidated. Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
Fossil insights into the developmental evolution of animal bodyplans during the “Cambrian Explosion”
PROJECT TITLE. Fossil insights into the developmental evolution of animal bodyplans during the “Cambrian Explosion”. Lead Institution. Read more
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Squeezing through small gaps: Understanding nuclear mechanics during invasive migration
Macrophages are highly migratory immune cells capable of engulfing and removing dead cells, debris and pathogens. Read more
4-year PhD Studentship: Control of neuronal differentiation and ciliogenesis through mineralocorticoid receptor (MR) – Regulatory Factor X (RFX) interaction in embryonic and adult neurogenesis
Glucocorticoid hormones (GCs) are of critical importance for health[1]. They bind to two receptor types in the hippocampus. the mineralocorticoid (MR) and glucocorticoid receptor (GR) which act as ligand-dependent transcription factors[2-4]. Read more
Embryonic stem cell patterning using microfabricated patterns of parylene-C
Micro-patterns of parylene-C on a SiO2 background can precisely guide the growth of neurons and astrocytes, derived from the rat hippocampus. Read more
Robustness of the molecular programme that drives cellular differentiation during embryonic blood cell development
Our body consists of numerous cell types that all fulfil very specific functions. Cellular differentiation is the process by which these cells arise from immature precursor cells during embryogenesis. Read more
MSc by Research: Does CDK1 regulate NICD turnover in a cell cycle dependant manner in Drosophila Melanogaster?
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life, including cell fate specification within progenitors. . Read more
Defining the role of WT1 in cellular and molecular processes during gastrulation, in embryos and gastruloids
In an ageing population, injury and degenerative processes lead to increased pressure on the NHS due to demand on treatments. Read more
Exploring the role of matrix encapsulation on early developmental decisions using non-animal sourced hydrogels
A PhD studentship in stem cell biology and disease modelling is available in Prof Merry’s group (. https://www.nottingham.ac.uk/medicine/people/cathy.merry. Read more
Understanding gene regulation by HDAC1 complexes in development and cancer
Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more
Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
Modelling Setbp1 haploinsufficiency disorder using hESC derived neurons and cerebral organoid cultures
Human brain development is a process tightly controlled by morphogens and transcription factors in a temporal- and spatial-dependent manner. Read more
The role of PHF6 during haematopoietic differentiation
PHD finger protein 6 (PHF6) is a protein, consisting of two atypical plant homeodomains (aPHD1/2) with nuclear and nucleolar localization sequences. Read more
Investigating novel molecular regulators of the brown adipocyte programme
Brown adipose tissue is an enigmatic tissue that plays an important role in energy metabolism. The increasing prevalence of obesity-related disorders has led to a growing need for therapeutic strategies to reverse diet-induced weight gain. Read more