We have 55 enzyme PhD Projects, Programmes & Scholarships

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enzyme PhD Projects, Programmes & Scholarships

We have 55 enzyme PhD Projects, Programmes & Scholarships

Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more

New Methods for modelling cofactor-dependent enzyme structure and function

Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more

Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more

Design and synthesis of novel enzyme substrates for the detection of pathogenic microorganisms (Ref: RDFC24/HLS/APP/TURNBULL)

FUNDED PROJECT - UK APPLICANTS ONLY. Background. This project builds upon a 30-year collaboration between Northumbria University, the Freeman Hospital (Newcastle upon Tyne NHS Trust), and bioMérieux – a multinational biotechnology company. Read more

Development of molecularly imprinted polymers (MIPs) assisted analytical methods for detection and monitoring of protein/enzyme biomarkers

Biomarkers have been used prolifically in the field of medicine to provide a rapid and easy method of monitoring many normal biochemical pathways and many pathological conditions without the need for any invasive procedures [1,2]. . Read more

Illuminating tissue barriers leading to treatment resistance and bowel cancer recurrence

Colorectal cancers are typically treated by chemotherapy, radiotherapy, and surgical removal. However, despite treatment, up to 50% of patients develop recurrence of disease – that is, the cancer returns either close to the original site or having spread to other places in the body. Read more

Wearable Sample Collection for Biosensing

Measurement of low abundance proteins is key for enabling early detection of diseases [1]. A widely used method for the measurement of low abundance proteins is enzyme-linked immunosorbent assay (ELISA) [2]. Read more

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Enzyme-responsive peptide hydrogels as in situ forming long-acting drug delivery implants

One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

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