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enzyme PhD Projects, Programmes & Scholarships

We have 67 enzyme PhD Projects, Programmes & Scholarships

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Using chemical-genetics to inhibit and characterise “undruggable” enzymes

University of Dundee School of Medicine
The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more
 Supervisors: Dr A Saurin, Dr T Ly
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

The University of Manchester Department of Chemistry
Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more
 Supervisors: Dr S Lovelock, Dr C Markin
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Effects of FADS2 single-nucleotide polymorphisms on clathrin-mediated endocytosis in human induced pluripotent stem cell-derived neurons

Cardiff University Cardiff School of Medicine
Hodge Centre for Translational Neuroscience. “Towards innovative treatments for mental illness”. Cardiff University Neuroscience and Mental Health Innovation Institute. Read more
 Supervisor: Prof A Harwood
 7 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Discovery of enzymes for plastic degradation

University of Nottingham School of Chemistry
Dr Luisa Ciano, Dr Anca Pordea and Dr Sam Bryan. Application deadline. open until filled, applications reviewed on a weekly basis. Read more
 Supervisors: Dr L Ciano, Dr A Pordea, Dr S Bryan
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

University of Nottingham School of Pharmacy
Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Regulation of CaaX protein processing

Queen’s University Belfast School of Pharmacy
USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types, as well as the migration of a range of cancer cells (NSCLC, breast, ovarian, osteosarcoma).    . Read more
 Supervisor: Dr J Burrows
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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A reactive fragment approach to dissect the zDHHC enzymes

University of Strathclyde Department of Pure and Applied Chemistry
Key Words: Synthetic Chemistry; Chemical Biology; Drug Discovery; Medicinal Chemistry; Organic Synthesis; Organic Chemistry. Read more
 Supervisors: Prof N Tomkinson, Prof L Chamberlain
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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FAIROmics - PhD fellowship in integrative bioinformatics and systems biology - From sequence to strain-specific phenotypes.

INRAE Inrae - Paris-Saclay Food and Bioproduct Engineering Research Unit
About the Project. Plant-based dairy and meat alternatives have grown in popularity in recent years for various reasons, including sustainability and health benefits, as well as lifestyle trends and dietary restrictions. Read more
 Supervisors: Prof BT Teusink, Dr DM Molenaar, Prof DR Remondini
 15 May 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Quantum Enhanced Single-Molecule Biosensing: Harnessing Entangled Photons with Whispering Gallery Mode Resonators

University of Exeter College of Engineering, Mathematics and Physical Sciences
Prof Frank Vollmer, Dr Charles Downing, University of Exeter. External collaborator. Prof Antonio Vidiella-Barranco, University of Campinas, Brazil. Read more
 Supervisor: Prof F Vollmer
 6 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Phosphonates: The Good, The Bad, and The Biodegradable

Queen’s University Belfast School of Biological Sciences
Organophosphonates are ancient molecules that contain the chemically stable C–P bond, which is considered a relic of the reducing atmosphere on primitive earth. Read more
 Supervisor: Prof G McMullan
 28 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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PhD in Supramolecular Chemistry: Metallo-Peptide Cages - Peptides as Adaptable Building Blocks in Metal-Organic Supramolecular Self-Assembly

King’s College London Department of Chemistry
We are a synthetic chemistry group working in supramolecular and biological chemistry, and nanotechnology. We work in the Francis Crick Institute in London, and at King's College London - find more details at https://www.mcternanresearchgroup.com/. Read more
 Supervisor: Dr CMT McTernan
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry
Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more
 Supervisors: Dr PA Ash, Dr H Kwon
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology
Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more
 Supervisors: Dr C Jenul, Prof D Jones
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences
Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more
 Supervisors: Dr H O'Hare, Dr N Garton
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding the roles of triacylglycerol in modulating mycobacterial growth and biophysical properties

University of Leicester Department of Respiratory Sciences
Mycobacteria contain more lipid than any other bacteria. In addition to a characteristically lipid-rich cell envelope, mycobacteria can accumulate triacylglycerol (TAG) as cytoplasmic lipid bodies (LBs). Read more
 Supervisors: Dr N Garton , Dr G Mukamolova
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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