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We have 68 enzymes PhD Projects, Programmes & Scholarships

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enzymes PhD Projects, Programmes & Scholarships

We have 68 enzymes PhD Projects, Programmes & Scholarships

Using chemical-genetics to inhibit and characterise “undruggable” enzymes

The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more

The role of ubiquitin-modifying enzymes in angiogenesis

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Structural insights into genome control by cohesin

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

PhD studentships in Biocatalysis

PhD studentships in Biocatalysis. Background and Aims. Natural and engineered biocatalysts are already having impact in the manufacture of high value pharmaceuticals by catalysing the conversion of functional groups in high yield. Read more

The identification of allosteric inhibitors of high value therapeutic targets

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more

A versatile approach to targeting mechanosensitive deubiquitinating enzymes (DUBs) in tissue damage and chronic inflammation using Molecularly Imprinted Nanoparticle Inhibitors (MINIs).

Inflammation is an essential defence mechanism adapted by our bodies to eliminate damaged cells, irritants and pathogens. However, persisting inflammation that fails to resolve promotes or contributes to a number of chronic diseases including cancer, rheumatoid arthritis and musculoskeletal diseases. Read more

Developing novel targeted therapeutic approaches through induced-proximity of proteins

Protein post-translational code is at the heart of protein function and signal transduction in cells. Enzymes catalyse the addition or removal of post-translational modifications (PTM), such as phosphorylation, methylation, acetylation, and ubiquitylation, on proteins. Read more

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more

Protein engineering enzymes for Industry

Project Overview. We are interested in key features of the protein sequence - structure - function relationship, and how this information can be translated to health. Read more

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