PhD in the Biosynthesis and Enzymology of Fluorine Containing Metabolites in Streptomyces Bacteria
Prof D O'Hagan
Applications accepted all year round
Research in the O’Hagan group has had a focus on the biosynthesis of fluorine containing natural products and the identification of a fluorination enzyme, ‘the fluorinase’, from Streptomyces cattleya. Fluorine is very rare in nature, and in those rare cases where an organism can form a C-F bond from fluoride ion, then the enzymology is unique and interesting.
Multiheme Cytochromes as Molecular Wires for Energy Technologies (BUTTJ2U19SF)
Prof J Butt, Dr T Clarke
31 May 2019
Certain bacteria have a natural ability to exchange electrons between their internal and external environments. This behavior allows coupling of catalytic transformations inside the bacteria to complementary redox transformations of catalysts and electrodes outside the cell.
Investigating the molecular mechanisms of the MORF complex in chromatin
Institute of Quantitative Biology, Biochemistry and Biotechnology
Dr M Wilson, Dr P Voigt
13 December 2018
Histone modifications play key roles in the regulation of gene expression. In embryonic stem cells, promoters of developmental genes carry a signature combination of histone H3 lysine 4 trimethylation (H3K4me3), which is usually found at active promoters, and H3K27me3, a hallmark of repressive chromatin.