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enzymology PhD Projects, Programs & Scholarships

We have 17 enzymology PhD Projects, Programs & Scholarships

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  PhD in the Biosynthesis and Enzymology of Fluorine Containing Metabolites in Streptomyces Bacteria
  Prof D O'Hagan
Applications accepted all year round
Research in the O’Hagan group has had a focus on the biosynthesis of fluorine containing natural products and the identification of a fluorination enzyme, ‘the fluorinase’, from Streptomyces cattleya.[1] Fluorine is very rare in nature, and in those rare cases where an organism can form a C-F bond from fluoride ion, then the enzymology is unique and interesting.
  MRC DiMeN DTP: Dissecting INPP5K function: cell biology, structural determination by X-ray crystallography and enzymology of a key protein implicated in muscular dystrophy, insulin signalling, spastic paraplegias and Parkinsonism
  Dr L Swan, Dr S Antonyuk, Dr M Stagi
Application Deadline: 21 January 2019
The Swan laboratory (https://www.researchgate.net/profile/Laura_Swan), specialists in phosphoinositide lipid biology and the cell biology of membrane trafficking, in collaboration with international teams of clinicians and scientists, have recently discovered that mutations in a specific phosphatase cause a congenital muscular dystrophy with short stature, brain and eye manifestations (papers.
  China Scholarship Council PhD Programme: How does protein S-acylation regulate plant growth and development?
  Dr P Hemsley
Application Deadline: 14 January 2019
S-acylation is an emerging lipid based post-translational modification affecting up to 40% membrane proteins. We have found that S-acylation in plants is a dynamic process allowing for regulation of protein function.
  Multiheme Cytochromes as Molecular Wires for Energy Technologies (BUTTJ2U19SF)
  Prof J Butt, Dr T Clarke
Application Deadline: 31 May 2019
Certain bacteria have a natural ability to exchange electrons between their internal and external environments. This behavior allows coupling of catalytic transformations inside the bacteria to complementary redox transformations of catalysts and electrodes outside the cell.
  Spectroscopy and Electrochemistry of Diheme Cytochromes (BUTTJ1U19SF)
  Prof J Butt, Dr M R Cheesman
Application Deadline: 31 May 2019
Pathogens such as Campylobacter jejuni can live in anaerobic environments through their ability to use tetrathionate, rather than oxygen, as a respiratory substrate.
  A hidden biochemical pathway in the chemical pathology of diabetes (HAMILTONCU19SF)
  Dr C Hamilton
Applications accepted all year round
In humans, the cysteine-containing tripeptide glutathione (GSH) is an essential thiol cofactor that maintains an intracellular reducing environment to protect against oxidative stress reactive oxygen species, which cause lipid, protein & DNA damage.
  Investigating the molecular mechanisms of the MORF complex in chromatin
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr M Wilson, Dr P Voigt
Application Deadline: 13 December 2018
Histone modifications play key roles in the regulation of gene expression. In embryonic stem cells, promoters of developmental genes carry a signature combination of histone H3 lysine 4 trimethylation (H3K4me3), which is usually found at active promoters, and H3K27me3, a hallmark of repressive chromatin.
  Investigating the role of induced histone marks in the repair of DNA damage
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr M Wilson, Dr S Buonomo
Application Deadline: 13 December 2018
Genome instability is a driver of cancer and understanding how the cell repairs DNA damage is critical to combating disease.
  (BBSRC DTP CASE) Driving enzymatic carboxylation using supercritical CO2
  Prof D Leys, Dr S Hay, Prof I Larrosa
Application Deadline: 31 January 2019
The use of CO2 as a chemical feedstock is attractive for various reasons, not least as a means to address the desirable reduction of global CO2 levels.
  (BBSRC DTP CASE) Exploitation of P450 BM3 variants for production of valuable biomolecules
  Prof A Munro, Prof D Leys
Application Deadline: 31 January 2019
The US Food and Drug Administration (FDA) have recommended that many human drug metabolites (as well as their parent drugs) should be subject to testing for safety/toxicity.
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