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We have 26 enzymology PhD Projects, Programmes & Scholarships



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enzymology PhD Projects, Programmes & Scholarships

We have 26 enzymology PhD Projects, Programmes & Scholarships

Structural and Mechanistic Characterisation of Bacterial Natural Product Targets

Natural products are a vital source of medicines and agrichemicals. For example, over 70% of the antibiotics on the World Health Organisation’s list of essential medicines are derived from natural sources (plants, bacteria or fungus). Read more

BBSRC NLD Doctoral Training Partnership: Investigating the mechanism of mucin degradation by a key member of the human gut microbiota

The human gut microbiota is closely associated with health, development and disease. The thick mucus layer in the colon is the key barrier between the contents of the lumen and the epithelial cells, providing protection against potential pathogens and environmental insults. Read more

The identification of allosteric inhibitors of high value therapeutic targets

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more

Unravelling the Molecular Mechanisms Behind Antibiotic Tolerance

Antibiotic resistance jeopardises our ability to effectively treat bacterial infections, yet it is not the only survival strategy pathogenic bacteria use to evade killing by antibiotics. Read more

Functional and structural characterisation of glycosyltransferases involved in protein mannosylation

Glycosylation is one the most abundant post-translational modifications and an evolutionary indicator. indeed the increasing complexity of host-pathogen and organism-environment interactions, amongst others, is reflected in the newly-reported ability of prokaryotes (e.g. Read more

Molecular level understanding of Mycobacterium tuberculosis

Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more

How does Clostridium perfringens colonise the human intestine?

Clostridium perfringens is a strictly anaerobic pathogen that produces a large number of different toxins. It causes a variety of intestinal diseases which are particularly lethal in very young infants. Read more

Bioprospecting for plastic-degrading enzymes from landfill

Plastic waste is a huge problem for most environments on Earth. This not only includes large collections of different plastics accumulating in different locations, such as landfills and Oceans, but also includes microplastics that are now understood to be infiltrating many different organisms and food chains. Read more

NERC E4 Ecophysiology and biochemistry of starch metabolism in fungal members of the rumen microbiome

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Sustainable ruminant farming is required to ensure global food security while mitigating environmental impacts. Ruminant performance, including greenhouse-gas emission, is critically impacted by activity of the microbiome. Read more

Introducing Artificial Metalloenzymes to Whole-Cell Biocatalysis

Background. Whole-cell biocatalysis is an attractive and cost-saving alternative to the use of purified enzymes. Given that the range of natural enzymes is limited, the potential of artificial metalloenzymes (ArMs) to create biocatalytic novelty is huge. Read more

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