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epigenetic PhD Projects, Programmes & Scholarships

We have 47 epigenetic PhD Projects, Programmes & Scholarships



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We have 47 epigenetic PhD Projects, Programmes & Scholarships

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Exploring the structure and inhibition of a novel epigenetic protein

Project description. It is now clear that our environment, diet, and lifestyle can cause our genes to be switched on or off. This is achieved primarily through chemical (or epigenetic) modifications on our DNA, RNA and histone proteins by a complex network of epigenetic proteins. Read more

The Mechanisms of Epigenetic Regulation in Ageing and Age-Related Neurodegeneration

We are seeking a bright, talented, and highly motivated PhD student to lead a project investigating basic mechanisms of epigenetic regulation and their involvement in ageing and age-related neurodegeneration. Read more

Deciphering a novel anti-ageing epigenetic programme

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more

Using epigenetic modifiers in combination with 5-FU based chemotherapy to elicit tumour specific immune responses and immunogenic cell death in colorectal cancer.

HDAC inhibitors (HDACi) are an emergent class of epigenetic modifying agent (EMA), with multi-modal mechanisms-of-action in both tumour and tumour microenvironment (TME). This project aims to understand how these drugs modulate efficacy of 5-FU-based chemotherapy to counteract transcriptional plasticity and immune evasion that underpins emergence of treatment resistance. Read more

Epigenetic regulation of cholangiocarcinoma growth

Cholangiocarcinoma (CCA) is a rare malignant bile duct tumour with an average incidence of 1/100,000 in the population per year. The overall incidence of CAA includes 15% of primary liver cancers, the second most common type of primary liver cancer. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks

The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more

MSc by Research: The epigenetic basis of blood diseases

The epigenetic mark of DNA methylation is established by DNMT (DNA methyltransferase) enzymes and has been shown to correlate with transcriptional states and influence cell identity and tumorigenesis in mammalian cells. Read more

The genetic and/or epigenetic nature of antifungal drug tolerance in Candida glabrata

To establish the molecular basis of antifungal drug tolerance in the human yeast pathogen Candida glabrata. Pathogenic fungi from the Candida genus are obligate human commensals, which cause disease when host immune systems are compromised. Read more

Revealing epigenetic signaling mechanisms in genome regulation and cancer.

We are looking for highly motivated PhD students to join our efforts to reveal epigenetic mechanisms that regulate the function of eukaryotic genomes in health and disease. Read more

Epigenetic mechanisms of phenotypic plasticity and the evolution of adaptive responses

We now live in a world of rapidly changing environmental conditions where species will need to adapt or perish. While populations may evolve in response to environmental change, more rapid responses may happen through processes like phenotypic plasticity. Read more
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Single-cell analysis of stress memory in plants

Plants are sessile organisms that are known for their adaptive plasticity to the changing environment. Environmental changes cannot only influence gene expression patterns but also affect the stability of the genome. Read more

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