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epigenetic PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 42 epigenetic PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Defining the Epigenome in Tendon Ageing

One hallmark of ageing is the accumulation of epigenetic alterations. There is a clear link between age and increasing incidence of tendon injury suggesting that the mechanical integrity of tendon declines with age. Read more

Epigenetic control of transcription factor regulation of adult neurogenesis in the dentate gyrus

In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more

Epigenetic regulation of skin wound healing

  Research Group: Chemistry and Biosciences
Skin in the largest organ in the human body consisting of epidermis, dermis and subcutis. It also contains epithelial appendages, including hair follicles and sweat glands. Read more

Evaluation of RNA Epigenetic modifications as non-invasive biomarkers for human diseases

The proposed project is within the broad area of biomedical genomics for healthy ageing. Globally, the major focus is to identify biomarkers for human diseases, that can help early diagnosis and prognosis of the disease towards a better management and a better quality of life for an ageing population. Read more

Cancer: Epigenetic therapy using microbubble-mediated drug delivery for colorectal cancer

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (including DNA methyltransferase inhibitors, HDAC inhibitors and/or vitamin C), as a potential combination therapy for colorectal cancer (CRC). Read more

Deciphering a novel anti-ageing epigenetic programme

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
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Epigenetic regulation of exophers (extracellular vesicles) biogenesis in Caenorhabditis elegans model organism

There are three main extracellular vesicles (EVs) categories. exosomes, microvesicles, and exophers. While EVs belonging to the first two categories are well characterized, the third class of EVs, exophers, was discovered very recently. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

Decoding the epigenetic mechanisms of drug resistance in aggressive breast cancers

Breast cancers pose a major health burden to modern world as being the most common cancer in women. Estrogen receptor (ER), the classical marker of 70% these cancers, is the nuclear receptor important for cancer progression. Read more

Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks

The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more

Cancer epigenetics and bioinformatics PhD project

About the Project. We are seeking a highly motivated student with high GPA preferably with knowledge of the following areas. bioinformatics, epigenetics/genetics/genomics. Read more

Epigenetic signalling in cancer

The advent of population scale tumour genomics has revealed that the genes encoding proteins that normally act to regulate chromatin structure are amongst the most frequently mutated genes in a range of cancers. Read more

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