The development of sustainable bio-manufacturing routes for both platform and high-value chemicals (e.g. biofuels, food supplement) is a high priority area to establish a low carbon economy and achieve energy/food security.
The production of chemicals from renewable sources is a key for a sustainable future. Various compounds can be produced by bacteria and yeast carrying synthetic metabolic pathways assembled of multiple genes derived from other organisms.
During exercise, and in the presence of sufficient oxygen, glucose is metabolised by muscle cells to produce pyruvate, a metabolic intermediate which is fed into the Kreb’s cycle in the mitochondria to produce large amounts of energy.
The Actinobacteria are important producers of approved drugs (>$1 billion dollars in 2016) but low yields of most natural products are a significant barrier to drug discovery, development and commercialisation.