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fibrosis PhD Projects, Programmes & Scholarships
We have 40 fibrosis PhD Projects, Programmes & Scholarships
Investigating the mechanisms for cardiac fibrosis development and reversal
Research interests/description of main research theme. Fibrosis is a hard to treat condition of major socioeconomic importance, with ~45% of all deaths in the developed world being attributed to some type of chronic fibro-proliferative disease and is exemplified by heart disease. Read more
Identification of novel therapeutic pathways for lung fibrosis and repair
Although many tissues have the capacity to repair following injury, the majority heal by fibrosis. Discovery of new targets is hampered by the lack of early-stage disease human tissue and the failure of animal models to recapitulate all aspects of clinical disease. Read more
Exploring mechanisms underlying viral infections in initiating pulmonary fibrosis
Respiratory viral infections are the most prevalent illnesses in humans. In addition to their immediate health effects, these infections can result in long-term lung conditions like pulmonary fibrosis and worsen existing chronic lung diseases. Read more
MSc by Research: Molecular characterisation of the factors driving lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that results in an irreversible decline in lung function. At present IPF is normally fatal and the median survival is between 2 and 5 years after diagnosis. Read more
Understanding the link between fibrosis, inflammation, and breast cancer initiation
Understanding the fundamental molecular events that result in tumour initiation is critical to the prevention and treatment of human cancers. Read more
Preclinical testing of collagen synthesis inhibitors for fibrotic disease
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
MSc (Res) project: Resolution versus persistence of fibrosis: The extracellular matrix decides (NDORMS-2025/5)
Fibrotic diseases affect multiple organ systems, increasing global morbidity and mortality1. Fibrosis is the final common pathway for a wide range of diseases affecting joint soft tissues including tendons, ligaments and synovial tissues2,3. Read more
Investigating the role of alveolar macrophage metabolic reprogramming in pathogenesis of progressive pulmonary fibrosis.
Progressive Pulmonary Fibrosis (PPF) is a devastating condition which causes worsening breathlessness and disability, with a high mortality rate. Read more
Investigating mechanisms of extra-cellular matrix remodelling and fibrosis in the gastrointestinal tract
Inflammatory bowel diseases, such as Crohn's disease, are increasing in prevalence globally. These are caused by chronic inflammation in the gut, there is no cure and medications are not effective for all. Read more
Functional effects of variable number tandem repeat expansions in idiopathic pulmonary fibrosis
Research Group:
Human & Medical Genetics
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by the formation of scar tissue in the lungs. Read more
Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.
Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more
MScR: Cystic fibrosis: restoring ion transport with small molecules
Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a unique ATP-binding cassette transporter that functions as an ATP-gated anion channel, playing a pivotal role in salt and water movement across epithelial tissues (1). Read more
Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.
Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more
Selective targeting of furin for the treatment of fibrotic lung disease.
Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more
Development of Nanomaterials for Targeting the Bacteria–Host Interface in Cystic Fibrosis Airways
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more