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folding PhD Projects, Programmes & Scholarships

We have 25 folding PhD Projects, Programmes & Scholarships

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We have 25 folding PhD Projects, Programmes & Scholarships

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Mechanistic structural studies on co‐translational folding and assembly of molecular motor proteins

All proteins are made up of amino acids, the building blocks of cells, which are strung together to make a peptide chain. True to the fundamental paradigm in cell biology i.e., structure determines function – the shape this string takes determines the role the protein will play inside a cell. Read more

3D genome folding and its role in DNA-based processes

The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more

Identifying new drug targets within Mycobacterium tuberculosis

  Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)
Tuberculosis (TB) is the leading cause of death worldwide and reflects a serious global health challenge. This bacterial pathogen kills more people than malaria and HIV combined, and is increasingly developing resistance to many of the current front-line drugs. Read more

Understanding nucleosome assembly: the interplay of order and disorder in histone chaperones

The genome of eukaryotic cells displays a hierarchy of structures that generate a tightly packed arrangement called chromatin. At the smallest scale, DNA molecules wind around protein complexes, the histone octamers, and together they form nucleosomes. Read more

Molecular characterization of Sam68-driven cytoskeletal reorganization

The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more

Early events in formation of the Immunological Synapse: Role of lipid microdomains in protein recruitment and sorting

  Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)
Background. The immunological synapse is a specialised cell-cell junction between an antigen presenting cell and a lymphocyte (T-cell) composed of >20 immune receptors that function in a concerted manner (Fig.1A). Read more

Energy Harvesting from Structural Movements Enhanced by Origami

In this project the techniques of origami and kirigami will be used to amplify the deformation of structural elements to optimise energy harvesting using piezoelectric materials. Read more

Metallo Foldamer-Proteins Hybrids Novel Biomimetic Scaffolds for Sensing and Imaging Applications

A PhD studentship is available in the groups of Dr Sarah Pike and Dr Anna Peacock (University of Birmingham) in the area of supramolecular and bioinorganic chemistry on the development of new foldamer-protein scaffolds for sensing and imaging applications. Read more

Using multimodal neuroimaging to predict individual differences in responsiveness to transcranial direct brain stimulation

Project outline. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can successfully modulate neural excitability and plasticity by delivering a small current via electrodes placed on the scalp. Read more

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