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folding PhD Projects, Programmes & Scholarships

We have 24 folding PhD Projects, Programmes & Scholarships

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Beyond AlphaFold: Experimental and computational folding of a de novo membrane protein

It has been suggested that the advent of AlphaFold has now “solved the protein folding problem”. In fact, understanding the precise steps that a protein must take in order to adopt a specific, functional threedimensional fold remains a very active area of research. Read more
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Mechanistic studies on protein folding and assembly of ciliary dynein motors.

All proteins are made up of amino acids, the building blocks of cells, which are strung together to make a peptide chain. Polypeptide chains get sculpted into their 3‐dimensional shapes to specify a cellular function by additional proteins called molecular chaperones and assembly factors. Read more

Self-folding Origami ”Robots” for Cognitive Smart Materials

Background: . With the development of smart materials capable of sensing and changing states, the realisation of 'robots' that are paper-like materials but that can fold themselves up, start moving, and adapt to the situation while sensing their environment is becoming a reality. Read more

Understanding the interaction and functional mechanism of mitochondrial MIA pathway

Mitochondria are vitally important organelles of living cells, which generate the primary energy for all biological activities. Mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Read more

Understanding control of genome folding by cohesin

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Identifying new drug targets within Mycobacterium tuberculosis

Tuberculosis (TB) is the leading cause of death worldwide and reflects a serious global health challenge. This bacterial pathogen kills more people than malaria and HIV combined, and is increasingly developing resistance to many of the current front-line drugs. Read more

Clock-watchER: Circadian coordination of the plant endoplasmic reticulum

The rotation of the Earth creates periodic day-night changes in environmental conditions such as light and temperature. Organisms are able to adapt to these predictable diurnal cycles through their internal timekeeping system, the circadian clock, which has a periodicity of approximately 24 hours. Read more

Translating magma intrusion into volcano surface deformation

Full details of this project and the NERC Panorama DTP funding scheme can be found here. Academic Supervisors. Dr Craig Magee <c.magee@leeds.ac.uk> (Institute of Geophysics and Tectonics, School of Earth & Environment, University of Leeds). Read more

EPSRC DTP 2024 PhD project: Applications for Constrained and functionalised Peptides and Proteins Using Organic Crosslinkers

The University of Bath is inviting applications for the following PhD project commencing on 30 September 2024 under the supervision of Prof Jody Mason in the Department of Life Sciences and Prof Tony James from the Department of Chemistry. Read more

Molecular characterization of Sam68-driven cytoskeletal reorganization

The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more

PhD in Supramolecular Chemistry: Metallo-Peptide Cages - Peptides as Adaptable Building Blocks in Metal-Organic Supramolecular Self-Assembly

We are a synthetic chemistry group working in supramolecular and biological chemistry, and nanotechnology. We work in the Francis Crick Institute in London, and at King's College London - find more details at https://www.mcternanresearchgroup.com/. Read more

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