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We have 120 g protein PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
g protein PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 120 g protein PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
Mapping the conformational signalling landscape of G protein-coupled receptors (GPCRs)
As a research group we are interested in the role that G protein-coupled receptors (GPCRs) play in cellular signalling. We aim at understanding how these membrane embedded receptors function and what external factors influence their behaviour as sensors of the cell. Read more
Structure, regulation and dynamics of small G proteins and their interactions with membranes and effector proteins
Our lab are interested in cell signalling via small G proteins of the Ras superfamily. We use a range of biochemical, biophysical and structural approaches to understand these fascinating proteins, which are involved in multiple cellular processes and are often deregulated in diseases such as cancer. Read more
Small G proteins and their effectors as therapeutic targets in cancer
For the majority of cancers the acquisition of invasive and metastatic characteristics leads to incurable disease in the host. Read more
Regulatory roles for ribosome-associated proteins in protein synthesis
Protein synthesis is a highly-conserved, dynamic and tightly controlled process that is central to the activity of all cells. All phases of translation can be controlled. Read more
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Universal Protein Monitoring Platform Based on Smart Holographic Sensor
This Sheffield-Singapore partnership aims at developing a universal protein monitoring platform to serve a wide range of industries (pharma, food, chemical) and to catapult protein R&D. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Molecular Mechanisms of Receptor and Ion Channel Regulation in Pain and Inflammation
"Receptors and ion channels are responsible for the transmission of signals across cellular membranes that regulate a plethora of biological and cellular functions. Read more
Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation
Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more
Enhancing Protein Thermal Stability for Melt Processing
Protein therapeutics are an important class of medicines with renowned efficacy in the treatment of several relevant disorders. Despite significant advantages, protein delivery remains a significant challenge. Read more
Design and synthesis of chemical tools to interrogate cannabinoid receptors
Research project. We are seeking a highly motivated PhD candidate to join an interdisciplinary team at the University of Otago, to undertake research developing chemical probes for the cannabinoid receptor, a type of G protein-coupled receptor (GPCR). Read more
EASTBIO: Cross talk between GPCRs and IL-33 dependent signalling in parasitic infection
The immune system plays important roles in both the response to infection and in tissue repair and homeostasis. It is a complex system made up of multiple specialised cell types, each of which must communicate with each other to coordinate an effective response. Read more
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Design, build and use of a light-sheet microscope for automated imaging of a zebrafish neurological disease model
Light-sheet fluorescence microscopy is a minimally-invasive imaging technique that can be used to observe living embryos as they develop. The aim of… Read more
How do nerves control blood flow in veins? (FOUNTAINS_U23BHF)
Veins contain around 70% of total blood volume and their tone determines the volume of blood returning to the heart, and hence regulate cardiac stroke volume. Read more
Impact of physical activity on the trajectory of neuromuscular ageing in humans
The PhD Scholarship “Impact of physical activity on the trajectory of neuromuscular ageing in humans” is fully funded by the University of Padova, Italy to support a full-time PhD student who is commencing research in the field of Biomedical Sciences. Read more