We have 104 g protein PhD Projects, Programmes & Scholarships

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g protein PhD Projects, Programmes & Scholarships

We have 104 g protein PhD Projects, Programmes & Scholarships

Investigating the roles that G protein coupled receptors play in hypertension

G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more

Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

The identification of allosteric inhibitors of high value therapeutic targets

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Design and synthesis of chemical tools to interrogate cannabinoid receptors - synthetic, medicinal chemistry

Research project. We are seeking a highly motivated PhD candidate to join an interdisciplinary team at the University of Otago, to undertake research developing chemical probes for the cannabinoid receptor, a type of G protein-coupled receptor (GPCR). Read more

Targeting Ras palmitoylation for the treatment of cancer

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Fully Funded PhD Scholarship in Use of pEEM for the quantitative analysis of protein-liposome interactions, NBL-4

Application(s) are invited from suitably qualified candidates for full-time funded PhD scholarship(s) starting in February 2024 affiliated to the Nanoscale Biophotonics Laboratory in the Discipline of Physics (School of Natural Sciences) at the University of Galway. Read more

Targeting the sweet tooth to curb population-wide sugar intake

Excess intake of dietary sugars are a major contributor to obesity, and type 2 diabetes and 82% of people state that taste is the major determinant of what they buy and eat. Read more

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