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We have 284 gene PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
gene PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 284 gene PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Partitioning primary and secondary changes of gene expression caused by gene mutations
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein. Read more
Haustoria-omics with proteomics, transcriptomics, and gene silencing, to understand fungal pathogenicity and plant resistance during powdery mildew disease in food crops
Powdery mildews (PMs) are prevalent plant diseases that compromise the production of many valuable food and horticultural crops, including cereals, strawberry, cucurbits and pea. Read more
Use it or lose it: what determines the regulation mode of a given gene?
All organisms must tightly control gene expression. In bacteria, gene regulation is mediated by either an activator or a repressor which binds DNA to turn a gene on or off, respectively. Read more
Gene Regulation in Cancer Metastasis
A PhD project in Gene Regulation in Cancer Metastasis is available in the laboratory of Dr Fiona Wardle (. https://www.kcl.ac.uk/research/wardle-group. Read more
Interrogating molecular switches that control developmental gene expression
The ability of cells and tissues to modulate rates of gene expression is critical for their ability to respond appropriately to cues during development, maintain normal function during ageing, and combat environmental insults and biological agents such as pathogens. Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
MSc by Research: Is control of gene expression at the translational level important for limb development?
Ribosomes are core components of all cells required for the translation of mRNA into protein. Read more
Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
Exploring how cancer cells transmit force into the nucleus to regulate gene expression
Overview. This project will explore the mechanobiology of skin cancer cells and seeks to understand the mechanisms by which force is transmitted from the tumour microenvironment into the nucleus. Read more
SynBac: Synthetic Baculovirus Genomes for Next-generation Drug Discovery and Gene Therapy
Baculovirus is a highly efficient delivery system for recombinant genes into eukaryotic cells, with great impact on the production of eukaryotic proteins, including high-value drug targets for pharmaceutical development. Read more
Combining Synthetic Biology and Modelling to Understand and Predict Evolution
Mutations, and their effects on organismal fitness, lie at the heart of understanding and predicting evolution. Because of its central role in determining evolutionary outcomes, much experimental and theoretical effort has been put into describing the fitness effects of mutations. Read more
Development of a gene activated construct targeting proinflammatory signalling to promote zonal regeneration of osteoarthritic cartilage
Current treatments fail to effectively repair cartilage and typically only delay the injury associated joint degeneration that leads to post-traumatic osteoarthritis (PT-OA). Read more
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Prenatal Gene Editing Tools for Sickle Cell Disease
This research proposal focuses on developing tools and methodologies for treating Sickle Cell Disease(SCD). Read more
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli.
Enteroaggregative Escherichia coli (EAEC) is a major cause of diarrhoeal disease in industrialized and non-industrialized countries and has been shown to be the cause of travellers’ diarrhoea and persistent diarrhoea in children and HIV patients. Read more
Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1
RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RAC1-NDD) that results from mutations in the RAC1 gene. Read more