Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein. Read more
Variation in gene regulation between animals often explains differences between species and individuals, and perturbed gene expression frequently underlies disease states. Read more
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
We investigate the molecular biology of African trypanosomes, with a particular focus on the epigenetic control of gene expression. Trypanosomes are… Read more
Our body consists of numerous cell types that all fulfil very specific functions. Cellular differentiation is the process by which these cells arise from immature precursor cells during embryogenesis. Read more
This is an exciting fully funded PhD studentship opportunity exploring the pathogenesis and treatment of human cardiac diseases with a potential for a vast array of 3D tissue engineering applications using advanced optical microscopy techniques. Read more
Pseudogenes are functionless remnants of DNA that are copied from parental genes during evolution. EP400 N-terminal-Like (EP400NL) gene was thought to be a pseudogene, located next to the parental EP400 gene in the chromosome. Read more
Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more
Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world-wide, accounting for over 66,000 deaths in the UK each year. Read more
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