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gene PhD Projects, Programmes & Scholarships
We have 309 gene PhD Projects, Programmes & Scholarships
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Laboratory of Gene Regulation
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Laboratory of Gene Regulation
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Partitioning primary and secondary changes of gene expression caused by gene mutations
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein. Read more
Long noncoding RNA control of Drosophila Hox gene expression
Variation in gene regulation between animals often explains differences between species and individuals, and perturbed gene expression frequently underlies disease states. Read more
4-year PhD Studentship: Apolipoprotein E-targeted stem cell gene therapy for people with Alzheimer’s disease
Alzheimer’s disease (AD) is a devastating progressive neurological disease, and a major increasing global health challenge. Read more
Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Regulation of variant antigen gene expression in African trypanosomes
We investigate the molecular biology of African trypanosomes, with a particular focus on the epigenetic control of gene expression. Trypanosomes are… Read more
Robustness of the molecular programme that drives cellular differentiation during embryonic blood cell development
Our body consists of numerous cell types that all fulfil very specific functions. Cellular differentiation is the process by which these cells arise from immature precursor cells during embryogenesis. Read more
Development and use of advanced optical microscopy to facilitate gene delivery and gene therapy in 3D cardiac disease models
This is an exciting fully funded PhD studentship opportunity exploring the pathogenesis and treatment of human cardiac diseases with a potential for a vast array of 3D tissue engineering applications using advanced optical microscopy techniques. Read more
Gene regulation using a CRISPR/Cas9-based histone variant deposition
Pseudogenes are functionless remnants of DNA that are copied from parental genes during evolution. EP400 N-terminal-Like (EP400NL) gene was thought to be a pseudogene, located next to the parental EP400 gene in the chromosome. Read more
4-year PhD Studentship: Nanoparticle Gene Therapy for Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent Mendelian inherited kidney disease (prevalence 1/1000). Read more
Self funded BMS Project: Understanding the population dynamics of haematopoietic stem cells during gene therapy for sickle cell disease
Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more
Functional coronary artery disease genetics - defining the function of new causal atherosclerosis genes from CAD GWAS loci using in vitro and in vivo models
Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world-wide, accounting for over 66,000 deaths in the UK each year. Read more
Apolipoprotein E-targeted stem cell gene therapy for people with Alzheimer’s disease
Perros Trust-supported 1 Year Full MSc R Scholarship for students of Black or Mixed Black Heritage backgrounds. Project Description. Read more