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gene delivery PhD Projects, Programs & Scholarships

We have 23 gene delivery PhD Projects, Programs & Scholarships

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  Non-viral gene therapy to prevent cartilage degeneration in Osteoarthritis
  Dr C Curtain, Dr O Kennedy, Dr F O'Brien
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) is the most common form of joint disease, affecting one in five people in the EU and results in activity limitations for approximately one in ten.
  Synthetic Virology: Development of gene delivery vectors/synthetic vaccines
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

There is worldwide interest in exploiting our modern understanding of genomics to target gene expression therapeutically via a variety of mechanisms, such as transgene insertion and CRISPR-Cas gene editing.
  Pharmacoengineering of advanced RNA-nanomedicines to treat cystic fibrosis (CF)
  Prof S Cryan, Prof A Heise, Prof C Greene
Applications accepted all year round

Funding Type

PhD Type

Cystic fibrosis (CF) is an inherited disorder caused by a mutation in a single gene responsible for the production of a protein called the cystic fibrosis transmembrane conductance regulator (CFTR).
  Developing optogenetic therapies for retinal degeneration
  Prof R Lucas, Dr Nina Milosavljevic
Applications accepted all year round

Funding Type

PhD Type

Retinal degeneration is the leading cause of blindness in developed countries. The new exciting biological approach of optogenetic therapy in which ectopic expression of photosensitive proteins (photopigments) is used to restore photosensitivity, offers a potential breakthrough for treating these conditions.
  Ultrasound-triggered microbubble vibration physics towards enhanced local drug delivery
  Dr B. Helfield
Applications accepted all year round

Funding Type

PhD Type

Sonoporation, the reversible and transient opening of cell plasma membranes using ultrasound and microbubbles, is an exciting new approach to targeted and local therapeutic delivery in cancer and cardiovascular disease applications.
  Creating “super” regulatory T cells to combat rejection, GVHD and autoimmunity through retroviral gene manipulation
  Dr N Jones, Dr S Lee
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Foxp3+CD25+CD4+ regulatory T cells (Treg) have been shown to be essential for the induction of tolerance to foreign organ transplants in experimental models.
  Developing dual-mode therapeutic systems to attack cancer tumours
  Prof D K Smith
Applications accepted all year round

Funding Type

PhD Type

Cancer is a challenging disease target, requiring wide-ranging strategies for intervention. Given the difficulties in treating recalcitrant tumours, multi-mode therapies are of significant potential value.
  A new Bioengineering Solution to Kidney Disease
  Prof S Ricardo
Application Deadline: 31 July 2020

Funding Type

PhD Type

The number of premature deaths due to chronic kidney disease (CKD) reflects the inadequacy of the currently available drugs and the growing epidemic worldwide.
  Non coding RNAs in Adrenocortical Cancer
  Prof G. Hutvagner
Applications accepted all year round

Funding Type

PhD Type

Background. Industry, society or clinical need for project and scientific rationale. Adrenocortical carcinoma (ACC) is a rare disease which occurs with an annual incidence of 2-4 cases per million with a five-year survival of less than 16-38%.
  Development of a novel therapeutic for the treatment of sickle cell anaemia
  Dr M Brennan, Prof M Devocelle
Applications accepted all year round

Funding Type

PhD Type

Sickle cell anaemia is a chronic condition that is expensive to treat and requires significant clinical intervention and management.
  Mapping the circadian clock-dependent regulation of the secretory pathway
  Prof K E Kadler, Dr Q-J Meng
Applications accepted all year round

Funding Type

PhD Type

The protein secretory pathway in cells comprises a series of membranous compartments and transport vesicles that the cell uses to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix.
  Molecular-genetic analysis of intra- and extra-cellular iron reduction systems in bacteria: role in gut colonisation and utilisation of dietary iron sources.
  Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

The innate immune defense systems respond to bacterial infection by reducing the amount of available iron in order to restrict bacterial growth.
  Molecular Mechanisms of Receptor and Ion Channel Regulation in Pain and Inflammation
  Dr G Cottrell, Dr D Widera, Dr S Amadesi, Dr A McNeish
Applications accepted all year round

Funding Type

PhD Type

"Receptors and ion channels are responsible for the transmission of signals across cellular membranes that regulate a plethora of biological and cellular functions.
  Obtaining mechanistic insights into interplay of multiple effectors of oncogenic RAS molecules
  Dr K Tanaka, Dr A Revyakin
Application Deadline: 7 June 2020

Funding Type

PhD Type

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. Importantly, about 20% of all human cancers harbour mutations in RAS genes (COSMIC).
  Personalised Medicine for Breast and Ovarian Cancer
  Dr N Buckley, Dr H McCarthy
Applications accepted all year round

Funding Type

PhD Type

One in two people will develop cancer in their lifetime and it is a leading cause of death. While significant progress has been made in the treatment of some cancers, there still remain some forms of the disease with limited treatment options and poor outcome.
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