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We have 54 gene regulation PhD Projects, Programmes & Scholarships

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gene regulation PhD Projects, Programmes & Scholarships

We have 54 gene regulation PhD Projects, Programmes & Scholarships

Gene regulation in cancer metastasis

A PhD project studying gene regulation in cancer metastasis is available in the laboratory of Dr. Fiona Wardle (https://www.kcl.ac.uk/research/wardle-group) in the Randall Centre for Cell and Molecular Biophysics, King’s College London. Read more

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

Project Background. Genome wide association studies (GWAS) have discovered many genetic associations with health outcomes. However, most GWAS signals reside in non-coding regions and it is likely that GWAS variants confer their effects through a regulatory mechanism. Read more

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Structural insights into genome control by cohesin

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

DNA-bending Proteins for Nanotech

  Research Group: Physics of Life
DNA is the molecule that nature uses as genetic material and it rarely exists in a relaxed state inside cells. Read more

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