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gene therapy PhD Projects, Programs & Scholarships

We have 36 gene therapy PhD Projects, Programs & Scholarships

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  Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development
  Dr V Hernandez
Applications accepted all year round

Funding Type

PhD Type

Bardet-Biedl syndrome (BBS) is a debilitating, often life-limiting heritable multisystem disorder caused by dysfunction of non-motile cilia (ciliopathy).
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Therapeutic models for Spinal muscular atrophy
  Prof R Yáñez-Muñoz
Applications accepted all year round

Funding Type

PhD Type

Our laboratory works on Gene Therapy in the Central Nervous System and Gene Repair, using novel viral vectors, gene targeting and induced pluripotent stem cells (iPSCs) as core technologies.
  Investigating the role of adenosine deaminase in motor neuron disease
  Dr S P Allen
Applications accepted all year round

Funding Type

PhD Type

In a recent study published in Brain (https://doi.org/10.1093/brain/awy353) and highlighted in a number of media articles (www.sheffield.ac.uk/news/nr/disrupted-pathway-motor-neurone-disease-1.830534) we have identified a novel disruption in an energy generating pathway in astrocytes (neuronal support cells) derived from motor neurone disease (MND) patients.
  Developing optogenetic therapies for retinal degeneration
  Prof R Lucas, Dr Nina Milosavljevic
Applications accepted all year round

Funding Type

PhD Type

Retinal degeneration is the leading cause of blindness in developed countries. The new exciting biological approach of optogenetic therapy in which ectopic expression of photosensitive proteins (photopigments) is used to restore photosensitivity, offers a potential breakthrough for treating these conditions.
  Identifying new therapeutic targets for diabetic heart disease
  Dr K Mellor
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a PhD student to work in the field of cellular and molecular cardiac research in the Department of Physiology, University of Auckland.
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Mitochondrial Genetics and Inherited Eye Diseases
  Dr P Yu-Wai-Man
Application Deadline: 3 December 2019

Funding Type

PhD Type

My research group is focused on new gene discovery and we are using a multipronged approach to dissect the disease pathways contributing to progressive neuronal loss and blindness, including zebrafish models and patient-derived induced pluripotent stem cells.
  Generation of transplant tissue following correction of patient stem cells by genomic engineering
  Dr F Manson, Dr RL Taylor, Dr A Adamson
Applications accepted all year round

Funding Type

PhD Type

A number of retinal degenerations result from mutations in genes expressed in the retinal pigment epithelium (RPE) which lies under the photoreceptors.
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