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gene therapy PhD Projects, Programs & Scholarships

We have 50 gene therapy PhD Projects, Programs & Scholarships

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  Development of Gene Therapy and Gene Editing for Lung Disorders: the translation of new gene therapies to the clinic, including the development of new vectors, and evaluation in animal models of disease.
  Dr D Gill, Dr S Hyde
Application Deadline: 11 January 2019
The Gene Medicine Research Group is based in the John Radcliffe Hospital and is focused on the development of new gene therapeutics for lung diesases.
  First steps towards gene therapy for congenital bladder disease
  Dr N Roberts, Prof A Woolf
Applications accepted all year round
In the congenital disease urofacial syndrome (UFS), urinary bladder voiding is incomplete due to poor co-ordination between detrusor muscle contraction and bladder outlet relaxation.
  3D Genomics for a better synthetic biology and gene therapy.
  Dr A Noy, Prof M Leake
Applications accepted all year round
While genome sequencing has led to significant increases in the amount of genetic information available, we are still far from a comprehensive understanding of how genomes work.
  Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteins
  Dr S Hyde, Dr D Gill
Application Deadline: 11 January 2019
We are focusing on strategies to deliver therapeutics via in vivo delivery of gene transfer vectors to generate ectopic “protein factories” capable of secreting therapeutic proteins into both the lung lumen and the systemic circulation.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round
The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round
Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Therapeutic models for Spinal muscular atrophy
  Prof R Yáñez-Muñoz
Applications accepted all year round
Our laboratory works on Gene Therapy in the Central Nervous System and Gene Repair, using novel viral vectors, gene targeting and induced pluripotent stem cells (iPSCs) as core technologies.
  Development of molecularly imprinted polymer nanoparticles (nanoMIPs) specific for anti-AAV antibodies, their characterisation and application
  Dr E Piletska
Application Deadline: 17 January 2019
The studentship aims at addressing the issue of pre-existing humoral immunity to Adeno-Associated Viruses (AAV), which is frequently found in humans, and prevents treatment with AAV vectors.
  (BBSRC DTP CASE) Native Mass Spectrometry approaches for Electron and Photon mediated Top Down Sequencing of Biotherapeutics
  Prof P Barran, Dr B Bellina
Application Deadline: 31 January 2019
In this project we propose to develop electron and photon mediated top-down sequencing methods to analyse recombinant biological therapeutics including monoclonal antibodies (mAbs) and adeno-associated viral (AAV) vectors.
  Understanding and curing genetic kidney disease.
  Prof M Saleem, Dr G Welsh
Applications accepted all year round
Genetic variation is the fundamental basis of inherited disease and acquired diseases such as cancer. Current technologies allow us to investigate diseases where only one or a small number of variants of genes are altered e.g CF or Huntingtons disease.
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