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gene therapy PhD Projects, Programs & Scholarships

We have 38 gene therapy PhD Projects, Programs & Scholarships

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  Development of Gene Therapy and Gene Editing for Lung Disorders: the translation of new gene therapies to the clinic, including the development of new vectors, and evaluation in animal models of disease.
  Dr D Gill, Dr S Hyde
Application Deadline: 26 July 2019
The Gene Medicine Research Group is based in the John Radcliffe Hospital and is focused on the development of new gene therapeutics for lung diesases.
  First steps towards gene therapy for congenital bladder disease
  Dr N Roberts, Prof A Woolf
Applications accepted all year round
In the congenital disease urofacial syndrome (UFS), urinary bladder voiding is incomplete due to poor co-ordination between detrusor muscle contraction and bladder outlet relaxation.
  Vascular-targeted gene therapy to block proliferation of smooth muscle cells using a novel adenovirus vector
  Prof A Baker, Dr D E Newby
Application Deadline: 1 April 2019
Many strategies have emerged to improve the function of the blood vessel wall following acute injury, including targeting endothelial cell function, vascular smooth muscle cell proliferation and migration and adventitial progenitor cells.
  3D Genomics for a better synthetic biology and gene therapy.
  Research Group: Physics of Life - Biological Physics and Biophysics
  Dr A Noy, Prof M Leake
Application Deadline: 1 September 2019
While genome sequencing has led to significant increases in the amount of genetic information available, we are still far from a comprehensive understanding of how genomes work.
  Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteins
  Dr S Hyde, Dr D Gill
Application Deadline: 26 July 2019
We are focusing on strategies to deliver therapeutics via in vivo delivery of gene transfer vectors to generate ectopic “protein factories” capable of secreting therapeutic proteins into both the lung lumen and the systemic circulation.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round
The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round
Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Therapeutic models for Spinal muscular atrophy
  Prof R Yáñez-Muñoz
Applications accepted all year round
Our laboratory works on Gene Therapy in the Central Nervous System and Gene Repair, using novel viral vectors, gene targeting and induced pluripotent stem cells (iPSCs) as core technologies.
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round
Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Computational design of DNAzymes as novel therapeutic molecules
  Dr A Marco, Dr G Brooke, Dr L Citi
Application Deadline: 6 May 2019
A brief overview of the studentship. This studentships is with School of Biological Sciences (lead), School of Computing Science and Electronic Engineering.
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