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gene therapy PhD Projects, Programs & Scholarships

We have 52 gene therapy PhD Projects, Programs & Scholarships

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  Gene therapy of Huntington’s disease: can we restore cognitive function through RNA-based treatment and cholinergic neuromodulation?
  Dr M Tsanov
Application Deadline: 22 June 2020

Funding Type

PhD Type

The proposed project explores the gene therapy of Huntington’s disease. We will compare the patterns of motor and cognitive improvement in rodent models of Huntington’s disease exposed to RNA-based gene therapy.
  Non-viral gene therapy to prevent cartilage degeneration in Osteoarthritis
  Dr C Curtain, Dr O Kennedy, Dr F O'Brien
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) is the most common form of joint disease, affecting one in five people in the EU and results in activity limitations for approximately one in ten.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Prof B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Therapeutic models for Spinal muscular atrophy
  Prof R Yáñez-Muñoz
Applications accepted all year round

Funding Type

PhD Type

Our laboratory works on Gene Therapy in the Central Nervous System and Gene Repair, using novel viral vectors, gene targeting and induced pluripotent stem cells (iPSCs) as core technologies.
  Pharmacoengineering of advanced RNA-nanomedicines to treat cystic fibrosis (CF)
  Prof S Cryan, Prof A Heise, Prof C Greene
Applications accepted all year round

Funding Type

PhD Type

Cystic fibrosis (CF) is an inherited disorder caused by a mutation in a single gene responsible for the production of a protein called the cystic fibrosis transmembrane conductance regulator (CFTR).
  Developing optogenetic therapies for retinal degeneration
  Prof R Lucas, Dr Nina Milosavljevic
Applications accepted all year round

Funding Type

PhD Type

Retinal degeneration is the leading cause of blindness in developed countries. The new exciting biological approach of optogenetic therapy in which ectopic expression of photosensitive proteins (photopigments) is used to restore photosensitivity, offers a potential breakthrough for treating these conditions.
  Investigating Therapeutic Effect of Different Antioxidants in Friedreich’s Ataxia (FRDA)
  Dr S Anjomani-Virmouni
Applications accepted all year round

Funding Type

PhD Type

Friedreich’s ataxia (FRDA) is an inherited neurodegenerative disorder caused by epigenetic silencing of the frataxin gene. It is the most common inherited ataxia, affecting 1:50,000 Caucasians, and is characterised by neurodegeneration, cardiomyopathy, diabetes mellitus and skeletal deformities.
  A new Bioengineering Solution to Kidney Disease
  Prof S Ricardo
Application Deadline: 31 July 2020

Funding Type

PhD Type

The number of premature deaths due to chronic kidney disease (CKD) reflects the inadequacy of the currently available drugs and the growing epidemic worldwide.
  Population-wide predictive pharmacogenomics for targeted RNA-cleaving and genome editing therapeutics (GEdit-SEQ) (Ref: SF20/APP/MOSCHOS3)
  Dr S Moschos
Applications accepted all year round

Funding Type

PhD Type

In the last decade a sleuth of interventions based on gene therapy and oligonucleotide therapeutics have received regulatory approval, paving the way for the era of personalised and N-of-1 medicine.
  Identifying new therapeutic targets for diabetic heart disease
  Dr K Mellor
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a PhD student to work in the field of cellular and molecular cardiac research in the Department of Physiology, University of Auckland.
  Molecular mechanisms of blood-brain barrier dysfunction and repair in epilepsy
  Dr C Ruedell Reschke, Prof D Henshall
Applications accepted all year round

Funding Type

PhD Type

Epilepsy is a common, chronic neurological disorder characterized by recurrent, unprovoked seizures. Current treatments fail at least one third of patients and we have no diseasemodifying therapies.
  Generation of universal donor transplant tissue by genomic engineering of induced pluripotent stem cells
  Dr F Manson, Dr T Wang
Applications accepted all year round

Funding Type

PhD Type

Project Description. Blindness can be caused by mutations in genes expressed in the retinal pigment epithelium (RPE), the tissue adjacent to the rod and cone photoreceptor cells that is essential for their normal function.
  Defining the molecular mechanisms underlying diastolic heart failure
  Prof LM Delbridge, Dr CL Curl
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a PhD student to join the Cardiac Phenomics laboratory at the University of Melbourne. Our University is ranked 9th in the world for pre-clinical biomedical research (Times Higher Education).
  Unravelling Stem Cell Heterogeneity
  Prof P G Genever
Application Deadline: 30 June 2020

Funding Type

PhD Type

Human mesenchymal stem/stromal cells (MSCs) are found in adult tissues such as bone marrow and are able to differentiate into bone, cartilage and fat tissues.
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