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gene expression PhD Projects, Programs & Scholarships

We have 218 gene expression PhD Projects, Programs & Scholarships

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  (BBSRC DTP) Partitioning primary and secondary changes of gene expression caused by gene mutations
  Dr D Talavera, Prof G D Pavitt, Dr J-M Schwartz
Application Deadline: 31 January 2019
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein.
  *IAPETUS* Gene expression and sexual selection in sex role reversed flies
  Research Group: Centre for Biological Diversity
  Prof MG Ritchie
Application Deadline: 18 January 2019
Empid flies (commonly known as dance flies) are exceptional in displaying elaborate sexually selected morphologies and behaviours in females.
  Evolutionary consequences of sexual mode switches on gene expression
  Dr R Hammond, Dr E Mallon
Application Deadline: 21 January 2019
The evolution of separate sexes - males and females (dioecy) – sets in train evolutionary conflicts between those genes that benefit females and those that benefit males.
  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 15 March 2019
CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019
Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
  Eukaryotic gene expression: understanding the role of UPF1 in global mRNA processing and amyotrophic lateral sclerosis (ALS)
  Dr S Brogna
Applications accepted all year round
This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  MRC DiMeN Doctoral Training Partnership: Gene expression network analysis to identify candidate drivers of treatment resistance in glioblastoma multiforme
  Dr A Droop, Dr L Stead, Prof D R Westhead
Application Deadline: 21 January 2019
Glioblastoma (GBM) is an incurable brain cancer. Patients survive an average 14 months post-diagnosis, despite receiving surgery and intensive chemoradiation because 100% of tumours grow back.
  Mechanisms of regulating gene expression via selective mRNA transport
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round
A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms.
  Upstream Open Reading Frames: A New Way to Turn Plant Genes On and Off?
  Prof B H Davies
Application Deadline: 20 January 2019
The ability to regulate gene expression is essential for life. Plants lack the ability to move and therefore have a particular challenge to respond to changes and trends in their environment and adjust the expression of their genes accordingly.
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