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genetic manipulation PhD Projects, Programs & Scholarships

We have 23 genetic manipulation PhD Projects, Programs & Scholarships

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  Defining the metabolic determinants of intestinal stem cell homeostasis
  Dr A Rufini, Prof F Giorgini
Application Deadline: 5 May 2019
The intestine is the fastest renewing organ. This ability is enabled by the presence of fast proliferating intestinal stem cells (ISCs) that reside in the crypts of Lieberkühn at the base of the intestinal villi.
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
  Research Group: BBSRC MIBTP
  Dr M Soller
Applications accepted all year round
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
  Genome mining of novel antimicrobial natural products from new bacterial strains
  Dr H Deng, Prof M Jaspars
Applications accepted all year round
Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Exploring aberrant inflammasome activation in chronic granulomatous disease
  Dr S Webster, Prof C E Bryant
Applications accepted all year round
This project will test the hypothesis. Aberrant inflammasome activation can be caused by mitochondrial ROS mediated NLRP3 inflammasome activation.
  How do antibiotic-producing bacteria decide when to synthesise antibiotics, and how much to make?
  Dr H O'Hare, Dr G Mukamolova
Application Deadline: 5 May 2019
Actinobacteria are well-known as producers of bioactive secondary metabolites including antibiotics, insecticides and immunosuppressants.
  Intestinal Immunology: exploring disease associated colonic mesenchymal populations, investigating molecular determinants of their evolution and function in barrier breakdown in IBD
  Prof A Simmons, Dr H Koohy
Application Deadline: 26 July 2019
We study how the intestinal immune system functions to enable the symbiotic relationship with the intestinal microflora required for health.
  Understanding and Treating Metabolic Liver Disease: Understanding the causes of non-alcoholic fatty liver disease to identify new biomarkers of disease stage as well as trial novel treatments
  Prof J Tomlinson, Prof L Hodson
Application Deadline: 26 July 2019
Understanding the causes of non-alcoholic fatty liver disease to identify new biomarkers of disease stage as well as trial novel treatments.
  The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis.
  Dr J Frayne
Applications accepted all year round
Development of systems for the generation of red blood cells (RBCs) from stem cells sources (adult peripheral blood, cord blood and pluripotent stem cells)…
  Serine/threonine protein kinase mediated regulation of protein secretion in mycobacteria
  Dr G Mukamolova, Dr H O'Hare
Application Deadline: 5 May 2019
Tuberculosis remains a major global threat as it affects humans and production animals. Mycobacterium tuberculosis and Mycobacterium bovis, the causative agents of tuberculosis in human and animals, are highly successful pathogens which secrete multiple virulence factors.
  Application of advanced spectroscopic techniques to monitor real-time transformations in aerosolized bovine tuberculosis bacteria
  Dr N Garton, Dr A Hudson
Application Deadline: 5 May 2019
Mycobacterium bovis is the causative agent of bovine tuberculosis (bTB), a devastating disease affecting global cattle populations.
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