DNA is commonly pictured as a perfect double helix, although it is mechanically distorted inside our bodies. Inside cells, DNA loops and ‘supercoils’ (coils on itself) to facilitate the main genetic operations such as gene activation and genome replication. Read more
While traditional, small molecule drugs continue to play a significant role due to their oral bioavailability, they also suffer from lower selectivity, frequently accompanied with side-effects. Read more
The Buonomo and Gilbert groups aim at building an understanding of the eukaryotic nuclear function that integrates knowledge from what are traditionally viewed as different fields, such as epigenetics, DNA replication and nuclear architecture. Read more
Crop production plays a crucial role in ensuring global food security and maintaining economic stability, especially with the global population projected to reach 9.8 billion by 2050, necessitating a 70% increase in food production. Read more
All cereal crops are grasses, meaning that the grass family provides more than 50% of global calories. The grass leaf underpins this crucial productivity and yet we do not understand the gene regulatory networks that control its development. Read more
All cereal crops are grasses, meaning that the grass family provides more than 50% of global calories. The grass leaf underpins this crucial productivity and yet we do not understand the gene regulatory networks that control its development. Read more
The Buonomo and Gilbert groups aim at building an understanding of the eukaryotic nuclear function that integrates knowledge from what are traditionally viewed as different fields, such as epigenetics, DNA replication and nuclear architecture. Read more
This project investigates the impact of natural genetic variations on a specific G protein-coupled receptor (GPCR), focusing on its structure, function, and drug interactions. Read more
Collaborators. Dr Paul Hole (Imophoron Ltd), Prof Robin Shattock (Imperial College), Dr Basam Hallis (UK Health Security Agency), Prof Lisa Ng (A*STAR SIngapore), Dr H Adrian Bunzel (ETH Zurich, Switzerland). Read more
Diabetes mellitus is a common cause of morbidity and mortality across the globe. Type 2 diabetes continues to rise in prevalence annually; from 1980 to 2004, Type 2 quadrupled in both prevalence and incidence [1]. Read more
Background. Nanotechnology is beginning to revolutionise the way that we design, build and use materials. For example, many COVID-19 vaccines contain nanoparticles that protect and deliver genetic material to cells. Read more
Background. Nanotechnology is beginning to revolutionise the way that we design, build and use materials. For example, many COVID-19 vaccines contain nanoparticles that protect and deliver genetic material to cells. Read more
Excess intake of dietary sugars are a major contributor to obesity, and type 2 diabetes and 82% of people state that taste is the major determinant of what they buy and eat. Read more
Project Overview. Ageing is associated with a decline in the functions of an organism (López-Otín, C. et al. Cell, 2023) and correlates with an increased risk of developing diseases in the later life (Niccoli, T. Read more
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