University of Sheffield Featured PhD Programmes
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University of Sheffield Featured PhD Programmes

genetic manipulation PhD Projects, Programs & Scholarships

We have 26 genetic manipulation PhD Projects, Programs & Scholarships

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We have 26 genetic manipulation PhD Projects, Programs & Scholarships

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Precision Medicine DTP – Why don’t spinal cord OPCs remyelinate well in multiple sclerosis and how do we fix it?

  Research Group: MRC Centre for Regenerative Medicine
Additional supervisor. Associate Prof Gonçalo Castelo Branco [Karolinska Institute]. Background. Oligodendrocytes are the myelin-forming cells of the central nervous system (CNS), providing both insulation to enhance nerve conduction velocity and metabolic support for the underlying axon. Read more
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Finding new antibiotics in the soil microbiota (MALONE_J22MMB)

The increase in drug-resistant bacterial infections is a major global health threat. This crisis is exacerbated by a lack of new antibiotics, caused by multiple factors including the frequent rediscovery of known antibiotics. Read more

Genome mining of novel antimicrobial and antiviral natural products from new bacterial strains

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses. Read more

Engineering biology for next-generation electronics: Building integrated bionanohybrid circuits by design.

Merging ideas and principles from biology with nanoscience has proved pivotal in improving our fundamental understanding of nature and the generation of new technologies that improve our everyday lives. Read more

Determining novel molecular regulators of necrosis controlling premature cell death

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases. Read more

Transcriptional control of vascular development

Sprouting of new capillaries from pre-existing vessels (angiogenesis) promotes the formation of almost all blood vessels during development, growth and tissue regeneration. Read more
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Precision Medicine DTP – 5α-Reductases: Mapping pathways of Metabolic Disease

  Research Group: Centre for Cardiovascular Science
Additional supervisors. Prof Li Wei [UCL] & Tom Michoel [University of Bergen]. Background. Glucocorticoid hormones regulate fuel homeostasis and are well recognised to induce cardio-vascular disease in excess1. Read more

Stem Cells: Developing pluripotent stem cell models of inherited retinal diseases

Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide. Read more

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