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genetic manipulation PhD Projects, Programs & Scholarships

We have 42 genetic manipulation PhD Projects, Programs & Scholarships

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  Physiological and molecular characterisation of altered root hydraulic properties in rice due to allelic variation or genetic manipulation of plasma membrane intrinsic proteins (PIPs, a class of aquaporins)
  Prof A Price
Applications accepted all year round
A cluster of three PIPs on chromosome 7 of rice are all candidate genes for a drought avoidance locus. These genes are highly expressed in roots and thought to have a major role in root hydraulic conductance.
  Defining the metabolic determinants of intestinal stem cell homeostasis
  Dr A Rufini, Prof F Giorgini
Application Deadline: 6 January 2019
The intestine is the fastest renewing organ. This ability is enabled by the presence of fast proliferating intestinal stem cells (ISCs) that reside in the crypts of Lieberkühn at the base of the intestinal villi.
  Exploring the molecular mechanisms of CREB activation in the human papillomavirus (HPV) infected epithelium
  Research Group: BBSRC White Rose DTP
  Dr A MacDonald, Prof A Whitehouse
Application Deadline: 7 January 2019
Overview. Human papillomaviruses re-wire an infected keratinocytes to drive virus replication and persistence. In so doing, they cause a number of devastating cancers in both sexes.
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
  Research Group: BBSRC MIBTP
  Dr M Soller
Application Deadline: 6 January 2019
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
  Exploring aberrant inflammasome activation in chronic granulomatous disease
  Dr S Webster, Prof C E Bryant
Applications accepted all year round
This project will test the hypothesis. Aberrant inflammasome activation can be caused by mitochondrial ROS mediated NLRP3 inflammasome activation.
  Molecular and physiological dissection of the unexpected metabolic actions of the DNA repair gene ataxia-telangiectasia mutated (ATM).
  Dr C Sutherland, Prof R McCrimmon, Prof E Pearson
Applications accepted all year round
Metformin is recommended as first line oral therapy in Type 2 diabetes (>200 million people world wide) in all international guidelines.
  How do antibiotic-producing bacteria decide when to synthesise antibiotics, and how much to make?
  Dr H O'Hare, Dr G Mukamolova
Applications accepted all year round
Actinobacteria are well-known as secondary metabolite producers and hence are of high interest commercially for drug discovery and for production of agrochemcials and human and animal therapeutics.
  How do antibiotic-producing bacteria decide when to synthesise antibiotics, and how much to make?
  Dr H O'Hare, Dr G Mukamolova
Application Deadline: 6 January 2019
Actinobacteria are well-known as producers of bioactive secondary metabolites including antibiotics, insecticides and immunosuppressants.
  Intestinal Immunology: exploring disease associated colonic mesenchymal populations, investigating molecular determinants of their evolution and function in barrier breakdown in IBD
  Prof A Simmons, Dr H Koohy
Application Deadline: 11 January 2019
We study how the intestinal immune system functions to enable the symbiotic relationship with the intestinal microflora required for health.
  Understanding and Treating Metabolic Liver Disease: Understanding the causes of non-alcoholic fatty liver disease to identify new biomarkers of disease stage as well as trial novel treatments
  Prof J Tomlinson, Prof L Hodson
Application Deadline: 11 January 2019
Understanding the causes of non-alcoholic fatty liver disease to identify new biomarkers of disease stage as well as trial novel treatments.
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